Machine Learning for Investigation on Endocrine-Disrupting Chemicals with Gestational Age and Delivery Time in a Longitudinal Cohort  

作　　者：Hemi Luan Hongzhi Zhao Jiufeng Li Yanqiu Zhou Jing Fang Hongxiu Liu Yuanyuan Li Wei Xia Shunqing Xu Zongwei Cai 

机构地区：[1]School of Medicine,Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,China [2]State Key Laboratory of Environmental and Biological Analysis,Department of Chemistry,Hong Kong Baptist University,Hong Kong,SAR,China [3]Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria,College of Environmental Science and Engineering,Nankai University,Tianjin 300350,China [4]Key Laboratory of Environment and Health,Ministry of Education&Ministry of Environmental Protection,and State Key Laboratory of Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China

出　　处：《Research》2022年第1期133-143,共11页研究（英文）

基　　金：support from the National Natural Science Foundation of China(Grant No.21904058);the National Key Research and Development Program of China(Grant No.2019YFC1804602);the Department of Education of Guangdong Province(Grant No.2020KZDZX1183).

摘　　要：Endocrine-disrupting chemicals(EDCs)are widespread environmental chemicals that are often considered as risk factors with weak activity on the hormone-dependent process of pregnancy.However,the adverse effects of EDCs in the body of pregnant women were underestimated.The interaction between dynamic concentration of EDCs and endogenous hormones(EHs)on gestational age and delivery time remains unclear.To define a temporal interaction between the EDCs and EHs during pregnancy,comprehensive,unbiased,and quantitative analyses of 33 EDCs and 14 EHs were performed for a longitudinal cohort with 2317 pregnant women.We developed a machine learning model with the dynamic concentration information of EDCs and EHs to predict gestational age with high accuracy in the longitudinal cohort of pregnant women.The optimal combination of EHs and EDCs can identify when labor occurs(time to delivery within two and four weeks,AUROC of 0.82).Our results revealed that the bisphenols and phthalates are more potent than partial EHs for gestational age or delivery time.This study represents the use of machine learning methods for quantitative analysis of pregnancy-related EDCs and EHs for understanding the EDCs’mixture effect on pregnancy with potential clinical utilities.

关 键 词：EDCS CHEMICALS INVESTIGATION 

分 类 号：R71[医药卫生—妇产科学]