Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays  

作　　者：Huan Wang Lijun Cai Dagan Zhang Luoran Shang Yuanjin Zhao 

机构地区：[1]Department of Clinical Laboratory,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210002,China [2]The Eighth Affiliated Hospital,Sun Yat-Sen University,Shenzhen 518033,China [3]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [4]Shanghai Xuhui Central Hospital,Zhongshan-Xuhui Hospital,and The Shanghai Key Laboratory of Medical Epigenetics,The International Co-Laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China [5]Chemistry and Biomedicine Innovation Center,Nanjing University,Nanjing 210023,China

出　　处：《Research》2022年第1期291-299,共9页研究（英文）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060,61927805,82102511,and 22002018);the Guangdong Basic and Applied Basic Research Foundation(2019A1515011750);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20190808120405672).

摘　　要：Micromotors with self-propelling ability demonstrate great values in highly sensitive analysis.Developing novel micromotors to achieve label-free multiplex assay is particularly intriguing in terms of detection efficiency.Herein,structural color micromotors(SCMs)were developed and employed for this purpose.The SCMs were derived from phase separation of droplet templates and exhibited a Janus structure with two distinct sections,including one with structural colors and the other providing catalytic selfpropelling functions.Besides,the SCMs were functionalized with ion-responsive aptamers,through which the interaction between the ions and aptamers resulted in the shift of the intrinsic color of the SCMs.It was demonstrated that the SCMs could realize multiplex label-free detection of ions based on their optical coding capacity and responsive behaviors.Moreover,the detection sensitivity was greatly improved benefiting from the autonomous motion of the SCMs which enhanced the ion-aptamer interactions.We anticipate that the SCMs can significantly promote the development of multiplex assay and biomedical fields.

关 键 词：TEMPLATE autonomous structural 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]