冠状动脉粥样硬化性心脏病患者血浆BNP、HCY、CysC水平与左心结构及功能的相关性分析  

Correlation Analysis of BNP, HCY and CysC Levels with Left Heart Structure and Function in Patients with Coronary Atherosclerosis

作　　者：潘如凤[1] 张恒[2] 吕宏安[1] 赵帅[1] 李妙男[2] 彭梅[3] PAN Ru-feng;ZHANG Heng;LU Hong-an;ZHAO Shuai;LI Miao-nan;PENG Mei(Department of Ultrasonography,The First Affiliated Hospital ofBengbu Medical College,Bengbu,Anhui,233004,China;Department of Internal Medicine-Cardiovascular,The First Affiliated Hospital ofBengbu Medical College,Bengbu,Anhui,233004,China;Department of Ultrasound Diagnosis,The Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui,230601,China)

机构地区：[1]蚌埠医学院第一附属医院超声科,安徽蚌埠233004 [2]蚌埠医学院第一附属医院心血管内科,安徽蚌埠233004 [3]安徽医科大学第二附属医院超声诊断科,安徽合肥230601

出　　处：《现代生物医学进展》2022年第3期557-560,476,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81572350);安徽省教育厅自然科学研究重点项目(KJ2018A0219)。

摘　　要：目的:探讨冠状动脉粥样硬化性心脏病(CHD)患者血浆脑肽钠(BNP)、同型半胱氨酸(HCY)、胱抑素C(CysC)表达水平及与左心结构及功能的相关性。方法:选择2018年12月至2021年4月本院收治的CHD患者80例(CHD组)和同期在本院进行体检的健康者80例(对照组)为研究对象,对比CHD组与对照组、不同美国纽约心脏病学会(NYHA)心功能分级的CHD患者血浆BNP、HCY、CysC水平及左心结构和功能指标,分析血浆BNP、HCY、CysC水平与左心结构和功能指标的相关性。结果:CHD组患者血浆BNP、HCY、CysC水平及室间隔厚度(IVS)、左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)、左室收缩末期容积(LVESv)、左室舒张末期容积(LVEDv)、左心室质量(LVM)水平高于对照组,左室射血分数(LVEF)水平低于对照组(P<0.05);血浆BNP、HCY、CysC及IVS、LVEDd、LVESd、LVESv、LVEDv、LVM水平Ⅰ级组低于Ⅱ级组,Ⅱ级组低于Ⅲ级组,Ⅲ级组低于Ⅳ级组(P<0.05);LVEF水平Ⅰ级组高于Ⅱ级组,Ⅱ级组高于Ⅲ级组,Ⅲ级组高于Ⅳ级组(P<0.05);血浆BNP、HCY、CysC水平与IVS、LVEDd、LVESd、LVESv、LVEDv、LVM水平呈正相关,与LVEF水平呈负相关(P<0.05)。结论:CHD患者血浆BNP、HCY、CysC水平异常升高,与左心结构及功能呈明显的相关性,BNP、HCY、CysC可能参与了CHD的病理过程。Objective: To investigate the expression of brain natriuretic peptide(BNP), homocysteine(HCY), Cystatin C(CysC) in the plasma of patients with coronary heart disease(CHD) and the correlation with left heart structure and function. Methods: 80 CHD patients(CHD group) and 80 healthy people(control group) who were treated in our hospital from December 2018 to April 2021 were selected as the subjects, the BNP, HCY, CysC levels and left heart structure and functional indexes between CHD group, control group and different New York Heart Association(NYHA) were compared. The correlation between plasma BNP, HCY, CysC levels and left ventricular structure and function was analyzed. Results: The levels of BNP, Hcy, CysC, ventricular septal thickness(IVS), left ventricular end diastolic diameter(LVEDd), left ventricular end systolic diameter(LVESd), left ventricular end systolic volume(LVESv), left ventricular end diastolic volume(LVEDv), left ventricular mass(LVM) were higher in CHD group than those in the control group, the left ventricular ejection fraction(LVEF) level was lower than that in the control group(P<0.05). The levels of BNP, HCY, CysC, IVS,LVEDd, LVESd, LVESv, LVEDv, LVM in plasma of classⅠgroup were lower than those of class Ⅱ group, class Ⅱ group was lower than that of Class Ⅲ group and class Ⅲ group lower than that of grade Ⅳ group(P<0.05). LVEF level in class Ⅰ group was higher than that of class Ⅱ group, level Ⅱ group was higher than grade Ⅲ group, and level Ⅲ group was higher than level Ⅳ group(P<0.05). The levels of BNP, HCY, CysC were positively correlated with IVS, LVEDd, LVESd, LVESv, LVEDv, LVM, and negatively correlated with LVEF(P<0.05). Conclusion: The levels of BNP, HCY and CysC in CHD patients were abnormally increased, which was significantly related to the left heart structure and function. BNP, HCY and CysC may be involved in the pathological process of CHD.

关 键 词：冠状动脉粥样硬化性心脏病 脑肽钠 同型半胱氨酸 胱抑素C 左心结构 左心功能 

分 类 号：R541.4[医药卫生—心血管疾病]