牙釉质仿生矿化研究进展  

Advances in researches on enamel biomimetic mineralization

作　　者：刘宝盈 栗博 王欣 王桐信 Liu Baoying;Li Bo;Wang Xin;Wang Tongxin(Department of Stomatology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450001,China;Department of Oral and Maxillofacial Pathology,College of Dentistry,Howard University,Washington DC 20059,USA)

机构地区：[1]郑州大学第一附属医院口腔科,郑州450001 [2]Department of Oral and Maxillofacial Pathology,College of Dentistry,Howard University,Washington DC 20059,USA

出　　处：《中华口腔医学杂志》2022年第3期307-313,共7页Chinese Journal of Stomatology

摘　　要：牙釉质仿生矿化是模仿牙齿形成的生物矿化机制,在体外模拟机体微环境,通过分子仿生合成和分子自组装等技术,构建类似牙釉质生理形成过程的微观条件,从而控制无机矿物晶体的形成过程,最终形成具有独特微观结构以及优异的生物学和理化性能的类牙釉质结构的过程。牙釉质结构破坏后的再矿化及仿生矿化修复是未来方向,有较大的临床应用需求及前景,近年研究进展迅速,研究成果引人瞩目。本文对相关进展作一综述。Dental enamel biomimetic mineralization is a process to form the enamel-like mineral structures,which possess unique microstructure and exceptional physic-chemical properties,by mimicking the mechanism of natural enamel formation and biomineralization.Varieties of techniques such as molecular mimetic synthesis and molecular self-assembling were used to accomplish the microenvironment and molecular conditions similar to that of natural tooth enamel within human body.Early remineralization and biomineralization is the future of restoration for enamel defect,research on such products have huge potential in clinical applications,with speedy advancement in recent two decades.This review summarizes the major advances in researches on enamel biomimetic mineralization in recent years.

关 键 词：牙釉质 牙再矿化 羟基磷灰石类 仿生材料 综述 

分 类 号：R781.1[医药卫生—口腔医学]