纳秒脉冲激光诱导的水中双空泡振荡研究  

Dynamics of Bubble Pairs in Water Induced by Focused Nanosecond Laser Pulse

作　　者：付磊 王萍 王斯佳[1] 辛静[1] 张璐薇 张镇西 王晶[1] 姚翠萍[1] Fu Lei;Wang Ping;Wang Sijia;Xin Jing;Zhang Luwei;Zhang Zhenxi;Wang Jing;Yao Cuiping(Key Laboratory of Biomedical Information Engineering of Ministry of Education,School of Life Science and Technology,Xi'an Jiaotong University,Xi'an,Shaanxi 710049,China;State Key Laboratory of Transient Optics and Photonics,Xi'an Institute of Optics and Precision Mechanics,Chinese Academy of Sciences,Xi'an,Shaanxi 710119,China)

机构地区：[1]西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室,陕西西安710049 [2]中国科学院西安光学精密机械研究所瞬态光学与光子技术国家重点实验室,陕西西安710119

出　　处：《中国激光》2022年第4期119-130,共12页Chinese Journal of Lasers

基　　金：国家自然科学基金(62005210,61727823,61775178,61975160);中德合作交流项目(M-0063);瞬态光学与光子技术国家重点实验室开放基金(SKLST202004);陕西省自然科学基金(2019-JQ-216)。

摘　　要：对水中不同间隔下的双空泡振荡行为的研究可为光致空化在生物医学领域的应用如微流体中的快速融合、细胞膜微手术等提供指导。通过将单脉冲激光分束,将激光从不同方向聚焦到水中,诱导大小、位置可控的两点击穿,形成具有相似尺寸的两个空化气泡,并引入高速摄像机,以及散射光检测和声学检测方法对双空泡振荡行为进行多方位测量。研究表明,对于能发生融合的双空泡,相对间隔的改变并不影响融合空泡的第一振荡周期,但能显著影响融合空泡振荡的非对称性、坍塌冲击波的形成及重建空泡的振荡。Objective Focused laser-induced cavitation in liquid is crucial in numerous applications,e.g.,targeted cell lysis,microfluidic operations(such as switching,pumping,and mixing),and perforation of cell membranes.Depending on the focusing conditions and laser pulse energy,single or multiple bubble formations may occur,which may be accompanied by bubble coalescence,high-speed jet formation,ring vortex generation,and multiple shock wave emission.Owing to its promising application prospect on microsurgery,micropumping,and tissue cutting,laserinduced multiple bubbles and their interactions have been studied extensively.It has been confirmed that the dynamics of multiple bubbles are strongly related to the relative bubble positions as well as the time and size difference between bubbles.For example,by adjusting these parameters,the strength and direction of the emerging liquid jets can be controlled.Shock wave and rebound bubbles generated after cavitation bubble collapse are susceptible to their asymmetrical collapse.Without a doubt,the mutual interaction of bubbles causes the asymmetrical oscillation process of bubbles.However,to the best of our knowledge,the influence of multiple bubble interactions on shock wave emission and rebound bubble process has not been studied yet.Therefore,in this study,two bubbles with similar sizes were generated using a single nanosecond laser pulse to investigate the influence of relative interval on multiple bubble dynamics,especially on collapse shock wave emission and rebound bubble generation.Methods A frequency-doubled Q-switched Nd:YAG laser was introduced to generate optical breakdown in water.The laser pulse was split into two parts using a variable beam splitter.Then,the split laser pulses were focused on water from different directions to generate bubble pairs.Three methods were introduced to measure the bubble pair dynamics:high-speed shadowgraph,optical scattering technique,and acoustic detection technique.It was easy to generate bubble pairs with variable relative interval b

关 键 词：生物光学 脉冲激光 光致空化 双空泡振荡 

分 类 号：R318.51[医药卫生—生物医学工程]