二维三七桂利嗪胶囊联合依达拉奉治疗脑梗死的临床研究  

Clinical study on Divitamins,Notoginseng and Cinnarizine Capsules combined with edaravone in treatment of ischemic cerebral infarction

作　　者：王春茹 陈念 王佩璐[2] 杨东锋 单春艳[3] WANG Chun-ru;CHEN Nian;WANG Pei-lu;YANG Dong-feng;SHAN Chun-yan(Department of Neurology,Ninghe District Hospital,Tianjin 301500,China;Department of Neurology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China;Department of Endocrinology,Metabolic Disease Hospital of Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津市宁河区医院神经内科,天津301500 [2]天津医科大学第二医院神经内科,天津300211 [3]天津医科大学代谢病医院内分泌科,天津300070

出　　处：《现代药物与临床》2022年第2期291-295,共5页Drugs & Clinic

基　　金：天津市科技计划项目(15ZXMFCY00062)。

摘　　要：目的探讨二维三七桂利嗪胶囊联合依达拉奉治疗脑梗死的临床效果。方法选择2019年1月—2019年12月天津市宁河区医院收治的80例脑梗死患者,根据信封法分为对照组和治疗组,每组各40例。对照组静脉滴注依达拉奉注射液,30 mg依达拉奉注射液加入100 mL生理盐水,2次/d。治疗组在对照组的基础上口服二维三七桂利嗪胶囊,1粒/次,1次/d。两组连续治疗2周。观察两组患者临床疗效,比较治疗前后两组患者日常生活能力(ADL)、美国国立卫生研究所卒中量表(NIHSS)评分,脑动脉血流速度及血管内皮功能和炎症因子水平。结果治疗后,治疗组总有效率明显高于对照组(P<0.05)。治疗后,两组患者ADL评分升高,而NIHSS评分明显降低(P<0.05),且治疗组评分明显好于对照组(P<0.05)。治疗后,两组患者大脑中动脉、大脑前动脉、大脑后动脉的血流速度明显加快,且治疗组明显快于对照组(P<0.05);治疗后,两组一氧化氮(NO)明显升高,而超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、内皮素1(ET-1)明显降低(P<0.05),且治疗组血管内皮功能和炎症因子水平明显好于对照组(P<0.05)。结论二维三七桂利嗪胶囊联合依达拉奉治疗脑梗死具有较好的临床疗效,在改善神经功能、脑动脉血流速度、生活自理能力方面效果显著,其主要作用机制可能与调节炎症、血管内皮功能有关。Objective To investigate the clinical effect of Divitamins,Notoginseng and Cinnarizine Capsules combined with edaravone in treatment of ischemic cerebral infarction.Methods Patients(80 cases)with ischemic cerebral infarction in Ninghe District Hospital from January 2019 to December 2019 were divided into control and treatment group according to envelope method,and each group had 40 cases.Patients in the control group were iv administered with Edaravone Injection,30 mg added into 100 mL normal saline,twice daily.Patients in the treatment group were po administered with Divitamins,Notoginseng and Cinnarizine Capsules on the basis of the control group,1 grain/time,once daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical evaluation was evaluated,the scores of ADL and NIHSS,the cerebral arterial blood flow velocity,and the vascular endothelial function and inflammatory factors in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was significantly higher than that of the control group(P<0.05).After treatment,ADL was significantly increased in two groups,but NIHSS were decreased(P<0.05),and these scores in the treatment group was significantly better than those in the control group(P<0.05).After treatment,the blood flow velocity of middle cerebral artery,anterior cerebral artery and posterior cerebral artery in two groups was significantly increased(P<0.05),which in the treatment group was significantly faster than that in the control group(P<0.05).After treatment,NO level was significantly increased in two groups,but the level of hs-CRP,TNF-α,ET-1 were significantly decreased(P<0.05),and the vascular endothelial function and inflammatory factors in the treatment group were significantly better than those in the control group(P<0.05).Conclusion Divitamins,Notoginseng and Cinnarizine Capsules combined with edaravone in treatment of ischemic cerebral infarction has a significant effect on improving neurological fun

关 键 词：二维三七桂利嗪胶囊 依达拉奉注射液 缺血性脑卒中 日常生活能力 脑动脉血流速度 血管内皮功能 

分 类 号：R971[医药卫生—药品]