小建中胶囊联合拉呋替丁治疗胃溃疡的临床研究  

Clinical study on Xiaojianzhong Capsules combined with lafutidine in treatment of gastric ulcer

作　　者：张俊[1] 王天锡[2] 魏蓉娜 ZHANG Jun;WANG Tian-xi;WEI Rong-na(Department of Traditional Chinese Medicine,Tianjin Beichen Hospital,Tianjin 300400,China;Department of Gastroenterology,Tianjin Nankai Hospital,Tianjin 300102,China)

机构地区：[1]天津市北辰医院中医科,天津300400 [2]天津市南开医院消化内科,天津300102

出　　处：《现代药物与临床》2022年第2期318-321,共4页Drugs & Clinic

基　　金：天津市卫生和计划生育委员会中医中西医结合科研课题(2017052)。

摘　　要：目的探讨小建中胶囊联合拉呋替丁治疗胃溃疡的临床研究。方法选取2019年6月—2021年6月在天津市北辰医院中医科诊治的126例胃溃疡患者,随机分为对照组和治疗组,每组各63例。对照组餐后口服拉呋替丁片,10 mg/次,2次/d。治疗组在对照组基础上口服小建中胶囊,3粒/次,3次/d。两组患者连续用药7 d。观察两组患者临床疗效,比较治疗前后两组临床症状缓解时间,胃动素(MTL)、胃泌素(GAS)和胆囊收缩素(CCK)水平,血清白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)水平,及不良反应情况。结果治疗后,治疗组患者临床总有效率明显高于对照组(98.41%vs 84.13%,P<0.05)。治疗后,治疗组患者临床症状缓解时间明显短于对照组(P<0.05)。治疗后,两组患者MTL水平明显升高,而GAS和CCK水平明显下降(P<0.05),且治疗组MTL、GAS和CCK水平明显好于对照组(P<0.05)。治疗后,两组患者血清IL-6、TNF-α和CRP水平明显降低,而IL-1β水平明显升高(P<0.05),且治疗组患者血清水平明显好于对照组(P<0.05)。治疗期间,治疗组药物不良反应发生率明显低于对照组(4.76%vs 11.21%,P<0.05)。结论小建中胶囊联合拉呋替丁治疗胃溃疡疗效显著,可有效缓解临床症状,并能降低炎症反应,加快溃疡面愈合,具有一定临床推广应用价值。Objective To explore the clinical study of Xiaojianzhong Capsules combined with lafutidine in treatment of gastric ulcer.Methods Patients(126 cases)with gastric ulcer in Tianjin Beichen Hospital from June 2019 to June 2021 were randomly divided into control and treatment group,and each group had 63 cases.Patients in the control group were po administered with Lafutidine Tablets after meals,10 mg/time,twice daily.Patients in the treatment group were po administered with Xiaojianzhong Capsules on the basis of the control group,3 grains/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluation was evaluated,the improvement time of clinical symptoms,the levels of MTL,GAS and CCK,the levels of IL-1β,IL-6,TNF-αand CRP,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the total clinical effective rate in the treatment group was significantly higher than that in the control group(98.41%vs 84.13%,P<0.05).After treatment,the relief time of clinical symptoms in the treatment group was significantly lower than that in the control group(P<0.05).After treatment,the level of MTL in two groups were significantly increased,while the levels of GAS and CCK were significantly decreased(P<0.05),and the levels of MTL,GAS and CCK in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the serum levels of IL-6,TNF-αand CRP in two groups were significantly decreased,while the level of IL-1βwere significantly increased,and the serum level in the treatment group was significantly better than that in the control group(P<0.05).During the treatment,the incidence of adverse drug reactions in the treatment group was significantly lower than that in the control group(4.76%vs 11.21%,P<0.05).Conclusion Xiaojianzhong Capsules combined with lafutidine in treatment of gastric ulcer has a significant effect,can effectively relieve clinical symptoms,reduce inflammatory reaction and speed up ulcer heali

关 键 词：小建中胶囊 拉呋替丁 胃溃疡 胃动素 胆囊收缩素 肿瘤坏死因子Α 不良反应 

分 类 号：R975[医药卫生—药品]