康乐鼻炎片联合西替利嗪治疗过敏性鼻炎的临床研究  

Clinical study on Kangle Biyan Tablets combined with cetirizine in treatment of allergic rhinitis

作　　者：徐广森 付文元[2] 曹震 王立英 XU Guang-sen;FU Wen-yuan;CAO Zhen;WANG Li-ying(Department of ENT,Sino-Singapore Eco-city Hospital of Tianjin Medical University,Tianjin 300480,China;Department of Otorhinolaryngology Head and Neck Surgery,Tianjin Third Central Hospital,Tianjin 300070,China)

机构地区：[1]天津医科大学中新生态城医院耳鼻喉科,天津300480 [2]天津市第三中心医院耳鼻喉头颈外科,天津300070

出　　处：《现代药物与临床》2022年第2期375-379,共5页Drugs & Clinic

摘　　要：目的探讨康乐鼻炎片联合盐酸西替利嗪治疗过敏性鼻炎的临床效果。方法选取2019年5月—2020年5月天津医科大学中新生态城医院收治的86例过敏性鼻炎患者,随机分成对照组和治疗组,每组各43例。对照组晚餐时口服盐酸西替利嗪片,1片/次,1次/d。治疗组在对照组基础上口服康乐鼻炎片,4片/次,3次/d。两组均连续治疗4周。观察两组患者临床疗效,比较治疗前后两组患者典型表现评分,鼻结膜炎生活质量调查问卷(RQLQ)总分,鼻功能指标总鼻气道阻力(NAR)、0~5 cm鼻腔容积(NCV)和鼻腔最小横截面积(NMCA),及血清白细胞介素-5(IL-5)、IL-16、可溶性E-选择素(sE-selectin)和嗜酸粒细胞趋化因子(Eotaxin)水平。结果治疗后,治疗组临床有效率为95.35%,显著高于对照组的79.07%(P<0.05)。治疗后,两组喷嚏、流涕、鼻塞、鼻痒评分及总分均显著低于治疗前(P<0.05),且以治疗组下降更显著(P<0.05)。治疗后,两组RQLQ总分和NAR总分较同组治疗前均显著下降,而0~5 cm NCV和NMCA均显著增大(P<0.05),且均以治疗组的改善更显著(P<0.05)。治疗后,两组血清IL-5、IL-16、sE-selectin和Eotaxin水平均显著低于本组治疗前(P<0.05),且治疗组明显低于对照组(P<0.05)。结论康乐鼻炎片联合盐酸西替利嗪治疗过敏性鼻炎的总体疗效确切,是减轻患者鼻部症状、改善鼻腔通气功能及提高生活质量的安全有效途径。Objective To investigate the clinical effect of Kangle Biyan Tablets combined with cetirizine in treatment of allergic rhinitis.Methods Patients(86 cases)with allergic rhinitis in Sino-Singapore Eco-city Hospital of Tianjin Medical University from May 2019 to May 2020 were randomly divided into control and treatment group,and each group had 43 cases.Patients in the control group were po administered with Cetirizine Hydrochloride Tablets after dinner,1 tablet/time,once daily.Patients the treatment group were po administered with Kangle Biyan Tablets on the basis of the control group,4 tablets/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluation was evaluated,the typical performance scores,RQLQ total scores,nasal function indicators NAR,0—5 cm NCV and NMCA,and the levels of serum IL-5,IL-16,sE-selectin and Eotaxin in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 95.35%,which was significantly higher than that of the control group(79.07%)(P<0.05).After treatment,the scores of sneezing,runny nose,stuffy nose and nasal itching,and total scores in two groups were significantly lower than those before treatment(P<0.05),especially in the treatment group(P<0.05).After treatment,the total score of RQLQ and total NAR in two groups were significantly lower than those in the same group before treatment,while 0—5 cm NCV and NMCA were significantly increased(P<0.05),and the improvement in the treatment group was more significant than those in the treatment group(P<0.05).After treatment,the serum concentrations of IL-5,IL-16,sE-selectin and Eotaxin in two groups were significantly lower than those before treatment(P<0.05),of Kangle Biyan Tablets combined with cetirizine in treatment of allergic rhinitis is definite,which is a safe and effective method to relieve nasal symptoms,improve nasal ventilation function and quality of life.

关 键 词：康乐鼻炎片 盐酸西替利嗪 过敏性鼻炎 鼻通气功能 可溶性E-选择素 嗜酸粒细胞趋化因子 

分 类 号：R987[医药卫生—药品]