中药干预高脂血症相关信号通路的研究进展  

Research progress of traditional Chinese medicine intervention on signaling pathway associated with hyperlipidemia

作　　者：裴帅[1] 曹宁宁 李晓璇 张琬靖 杨文静 肖学凤[1] PEI Shuai;CAO Ningning;LI Xiaoxuan;ZHANG Wanjing;YANG Wenjing;XIAO Xuefeng(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;International industrial Center,Tasly Holding Group Co.,Ltd.,Tianjin 300410,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]天士力医药集团股份有限公司国际产业中心,天津300410

出　　处：《药物评价研究》2022年第1期177-185,共9页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(81973557);天津市自然科学基金重点项目(20JCZDJC00010);国家科技重大专项(2018ZX09737-019、2018ZX09303-024);释药技术与药代动力学国家重点实验室(天津药物研究院)开发课题资助(010162001)。

摘　　要：高脂血症是因多种原因导致脂质代谢紊乱的一种病理状态,可引起动脉粥样硬化等多种疾病的发生,严重影响患者的生活质量。目前化学药治疗存在不良反应大、耐药等缺点。而中药用于治疗高脂血症的历史悠久,临床经验丰富,且以不良反应少、用药依从性好的优点成为近几年研究的热点。通过查阅分析国内外有关中药干预高脂血症信号通路的文献,归纳总结出6条中药干预高脂血症相关信号通路,分别为过氧化物酶体增殖物激活受体(PPAR)信号通路、腺苷酸激活蛋白激酶(AMPK)信号通路、环磷酸腺苷(cAMP)信号通路、脂肪细胞因子(Adipocytokine)信号通路、法尼酯衍生物X受体(FXR)-小异二聚体伴侣(SHP)信号通路及磷脂酰肌醇-3-激酶(PI3K)-丝氨酸/蛋白激酶B(Akt)信号通路,以期为治疗高脂血症的药物研发提供参考。Hyperlipidemia is a pathological condition of lipid metabolism disorder due to a variety of reasons,which can cause atherosclerosis and other diseases,and seriously affect patients'quality of life.At present,western medicine in the treatment of hyperlipidemia has many disadvantages such as high side effects,drug resistance and so on.However,traditional Chinese medicine has a long history in the treatment of hyperlipidemia,with rich clinical experience.Traditional Chinese medicine has become a hot topic in recent years due to its advantages of less side effects and good compliance.In this paper,by consulting and analyzing the local and international literatures on the signaling pathway of traditional Chinese medicine in the treatment of hyperlipidemia,the six signaling pathways of traditional Chinese medicine intervention on signaling pathway associated with hyperlipidemia are summarized,which were PPAR,AMPK,cAMP,Adipocytokine,FXR-SHP and PI3K-AKT,respectively,so as to provide reference for the research and development of drugs for hyperlipidemia.

关 键 词：中药 高脂血症 信号通路 过氧化物酶体增殖物激活受体信号通路 腺苷酸激活蛋白激酶信号通路 环磷酸腺苷信号通路 脂肪细胞因子信号通路 法尼酯衍生物X受体-小异二聚体伴侣信号通路 磷脂酰肌醇-3-激酶-丝氨酸/蛋白激酶B信号通路 

分 类 号：R926[医药卫生—药学]