双水平正压通气联合固尔苏治疗新生儿呼吸窘迫综合征的临床研究  

Clinical study of bilevel positive pressure ventilation combined with Curosurf in treatment of neonatal respiratory distress syndrome

作　　者：张红阳 ZHANG Hong-yang(Department of Neonatal Intensive Care,Nanyang the First People’s Hospital,Nanyang,Henan 473000,China)

机构地区：[1]南阳市第一人民医院新生儿重症监护科,河南南阳473000

出　　处：《医药论坛杂志》2022年第2期36-38,43,共4页Journal of Medical Forum

摘　　要：目的探讨新生儿呼吸窘迫综合征(NRDS)患儿采用双水平正压通气(BiPAP)联合固尔苏治疗的临床效果。方法选择2019年1月—2021年6月期间南阳市第一人民医院收治的70例NRDS患儿作为研究对象,随机分为对照组(n=35)与观察组(n=35)。两组均实施常规对症治疗,在此基础上,对照组采取BiPAP治疗,观察组采用BiPAP联合固尔苏治疗,两组均治疗3 d。比较两组临床指标,比较两组治疗前及治疗3 d血气指标[动脉血压分压(PaO_(2))、二氧化碳分压(PaCO_(2))、氧合指数(OI)],比较两组并发症发生情况(败血症、肺出血、气胸)。结果观察组机械通气时间(51.28±11.76)h、氧疗时间(63.14±12.11)h、住院时间(17.26±4.35)d均短于对照组(60.74±11.58)h、(78.97±12.35)h、(24.16±4.77)d,差异有统计学意义(P<0.05);治疗3d,两组PaO_(2)、OI水平高于治疗前,PaCO_(2)水平低于治疗前,且观察组PaO_(2)(88.64±8.48)mm Hg、OI(397.46±20.46)mm Hg水平高于对照组,PaCO_(2)(38.79±4.26)mm Hg水平低于对照组(80.39±8.32)mm Hg、(375.59±20.17)mm Hg、(42.84±4.32)mm Hg,差异有统计学意义(P<0.05);观察组并发症发生率(5.71%)与对照组比较(2.86%)比较,差异无统计学意义(P>0.05)。结论 BiPAP联合固尔苏可有效改善NRDS患儿的血气指标,缩短其机械通气、氧疗及住院时间,促进患儿康复,且未增加并发症发生风险,安全性较佳。Objective To investigate the clinical effect of Bilevel positive pressure ventilation(BiPAP) combined with Curosurf in the treatment of neonatal respiratory distress syndrome(NRDS).Methods Totally 70 children with NRDS treated in Nanyang First People’s Hospital from January 2019 to June 2021 were selected as the research subjects,the random number table method was used to divide them into control group(n=35) and observation group(n=35).Both groups were treated with routine symptomatic treatment,on this basis,the control group was treated with BiPAP and the observation group was treated with BiPAP combined with Curosurf,both groups were treated for 3 days.The clinical indexes of the two groups(mechanical ventilation time,oxygen therapy time and hospitalization time) were compared,the blood gas indexes [arterial blood pressure partial pressure(PaO_(2)),carbon dioxide partial pressure(PaCO_(2)) and oxygenation index(OI)] before treatment and 3 days after treatment were compared between the two groups,the complications(sepsis,pulmonary hemorrhage,pneumothorax) were compared between the two groups.Results The mechanical ventilation time(51.28±11.76) h,oxygen therapy time(63.14±12.11) h and hospitalization time(17.26±4.35) d in the observation group were shorter than those in the control group(60.74±11.58) h,(78.97±12.35) h and(24.16±4.77) d,the differences were statistically significant(P<0.05);Compared with before treatment,the levels of PaO_(2) and OI were higher,the level of PaCO_(2) was lower 3 days after treatment in both groups,compared with the control group(80.39±8.32) mm Hg,(375.59±20.17) mm Hg and(42.84±4.32) mm Hg,the levels of PaO_(2)(88.64±8.48) mm Hg and OI(397.46±20.46) mm Hg were higher,and the level of PaCO_(2)(38.79±4.26) mm Hg was lower in the observation group,the differences were statistically significant(P<0.05);There was no statistical significant difference in comparison of the incidence of complications between the observation group(5.71%) and the control group(2.86%)(P>0.05).Con

关 键 词：新生儿呼吸窘迫综合征 双水平正压通气 固尔苏 血气指标 并发症 

分 类 号：R563.8[医药卫生—呼吸系统]