七叶皂苷钠联合纳洛酮治疗高血压脑出血临床研究  

Clinical Study of Sodium Aescinate Combined with Naloxone in the Treatment of Hypertensive Intracerebral Hemorrhage

作　　者：陈海 蒋佳莉 李华敏 刘丽霞 CHEN Hai;JIANG Jiali;LI Huamin;LIU Lixia(Hainan West Central Hospital,Danzhou,Hainan,China 571700)

机构地区：[1]海南西部中心医院,海南儋州571700

出　　处：《中国药业》2022年第7期92-94,共3页China Pharmaceuticals

基　　金：海南省卫生计生行业科研项目[18A200156]。

摘　　要：目的探讨七叶皂苷钠联合纳洛酮治疗高血压脑出血的临床疗效,以及对患者高迁移率族蛋白B_(1)(HMGB_(1))、基质金属蛋白酶9(MMP-9)水平的影响。方法选取医院2018年9月至2020年9月收治的高血压脑出血患者104例,按随机数字表法分为观察组和对照组,各52例。两组患者均予纳洛酮治疗,观察组患者加用七叶皂苷钠,均连续治疗2周。结果观察组自愿退出1例、失访2例,对照组自愿退出1例、失访1例、调整治疗方案2例,均予以剔除。观察组总有效率为91.84%,显著高于对照组的72.92%(P<0.05);治疗后,观察组患者的美国国立卫生研究院卒中量表评分显著低于对照组,格拉斯哥昏迷指数量表评分、蒙特利尔认知评估量表评分均显著高于对照组(P<0.05);观察组患者的HMGB_(1)和MMP-9水平均显著低于对照组(P<0.05);观察组患者的高切全血黏度、中切全血黏度、低切全血黏度水平均显著低于对照组(P<0.05);观察组和对照组治疗期间不良反应发生率相当(16.33%比10.42%,P>0.05)。结论七叶皂苷钠联合纳洛酮治疗高血压脑出血疗效良好,可降低患者的HMGB_(1)和MMP-9水平,改善血液循环,且安全性良好。Objective To investigate the clinical efficacy of sodium aescinate combined with naloxone in the treatment of hypertensive intracerebral hemorrhage and its effect on the levels of high mobility group protein B_(1)(HMGB_(1))and matrix metalloproteinase-9(MMP-9).Methods A total of 104 patients with hypertensive intracerebral hemorrhage admitted to the hospital from September 2018 to September 2020 were selected and divided into the observation group and the control group according to the random number table method,with 52 cases in each group.The patients in the two groups were treated with naloxone,on this basis,the patients in the observation group were treated with sodium aescinate.Both groups were treated for two consecutive weeks.Results One case voluntarily withdrew and two cases were lost to follow-up in the observation group,while one case voluntarily withdrew,one case was lost to follow-up and two cases adjusted the treatment plan in the control group,all the above patients were excluded.The total effective rate of the observation group was 91.84%,which was significantly higher than 72.92%of the control group(P<0.05).After treatment,the score of the National Institute of Health Stroke Scale(NIHSS)in the observation group was significantly lower than that in the control group,while the scores of Glasgow coma scale(GCS)and Montreal Cognitive Assessment Scale(MoCA)in the observation group were significantly higher than those in the control group(P<0.05).The levels of HMGB_(1) and MMP-9 in the observation group were significantly lower than those in the control group(P<0.05).The levels of high-shear whole blood viscosity,medium-shear whole blood viscosity and low-shear whole blood viscosity in the observation group were significantly lower than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions in the observation group was similar to that in the control group(16.33%vs.10.42%,P>0.05).Conclusion Sodium aescinate combined with naloxone is effective and safe in the treatment

关 键 词：高血压脑出血 七叶皂苷钠 纳洛酮 高迁移率族蛋白B_(1) 基质金属蛋白酶9 

分 类 号：R969.4[医药卫生—药理学] R972.4[医药卫生—药学]