布地格福吸入气雾剂联合肺康复训练对中重度慢阻肺患者的影响  

Effect of budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with pulmonary rehabilitation training on patients with moderate to severe chronic obstructive pulmonary disease

作　　者：姚剑坤 李翠君 欧阳细瑜 吴小锋 YAO Jian-kun;LI Cui-jun;OUYANG Xi-yu(Foshan Fifth People’s Hospital,Foshan 528211,China)

机构地区：[1]佛山市第五人民医院,528211

出　　处：《中国实用医药》2022年第6期29-32,共4页China Practical Medicine

摘　　要：目的观察分析布地格福吸入气雾剂联合肺康复训练对中重度慢性阻塞性肺疾病(慢阻肺)患者的影响。方法127例中重度慢阻肺患者,依据收治时间分为对照组(2020年5月前收治,62例)与研究组(2020年5月后收治,65例)。对照组采取布地奈德福莫特罗吸入粉剂联合肺功能康复训练,研究组采取布地格福吸入气雾剂联合肺功能康复训练。比较两组治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、肺活量(VC)占预计值百分比、第1秒用力呼气容积与用力肺活量的比值(FEV1/FVC)]与血气指标[血氧饱和度(SpO_(2))、动脉血氧分压(PaO_(2))]水平、圣乔治呼吸问卷(SGRQ)评分、慢阻肺疾病评估测试(CAT)评分。结果治疗后,两组FEV1、FVC、VC占预计值百分比、FEV1/FVC、PaO_(2)、SpO_(2)水平均高于本组治疗前,且研究组高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组SGRQ、CAT评分均低于本组治疗前,且研究组SGRQ评分(37.52±4.49)分、CAT评分(16.58±2.61)分,均低于对照组的(45.02±5.04)、(21.77±1.62)分,差异均有统计学意义(P<0.05)。结论中重度慢阻肺患者运用布地格福吸入气雾剂联合肺康复训练,可明显的改善患者的肺功能与血气指标,降低疾病对生活的影响,效果理想。Objective To observe and analyze the effect of budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with pulmonary rehabilitation training on patients with moderate and severe chronic obstructive pulmonary disease.Methods A total of 127 patients with moderate to severe chronic obstructive pulmonary disease were divided into the control group(treated before May 2020,62 cases)and the research group(treated after May 2020,65 cases)according to the time of admission.The control group received budesonide and formoterol fumarate powder for inhalation combined with pulmonary function rehabilitation training,while the research group received budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with pulmonary function rehabilitation training.Both groups were compared in terms of pulmonary function indicators[forced expiratory volume in the 1st second(FEV1),forced vital capacity(FVC),vital capacity(VC)as a percentage of the predicted value,ratio of FEV1 to forced vital capacity(FEV1/FVC)]and blood gas indicators[blood oxygen saturation(SpO_(2)),arterial partial pressure of oxygen(PaO_(2))],St.George’s Respiratory Questionnaire(SGRQ)score,COPD Assessment Test(CAT)score before and after treatment.Results After treatment,the FEV1,FVC,VC as a percentage of the predicted value,FEV1/FVC,PaO_(2),SpO_(2)in the two groups were higher than those of this group before treatment,and the research group was higher than the control group.All the differences were statistically significant(P<0.05).After treatment,the SGRQ and CAT scores of the two groups were lower than those of this group before treatment,and the SGRQ and CAT scores of the research group were(37.52±4.49)and(16.58±2.61)points,which were lower than(45.02±5.04)and(21.77±1.62)points of the control group.All the differences were statistically significant(P<0.05).Conclusion Budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with pulmonary rehabilitation training has ideal e

关 键 词：布地格福吸入气雾剂 肺康复训练 中重度慢性阻塞性肺疾病 

分 类 号：R473.5[医药卫生—护理学]