右美托咪定复合异丙酚和瑞芬太尼在烧伤患者围手术期麻醉中的应用效果观察  

Application effect of dexmedetomidine combined with propofol and remifentanil in perioperative anesthesia in burn patients

作　　者：范思苑 张彩玲 FAN Si-yuan;ZHANG Cai-ling(Meizhou Hospital of Traditional Chinese Medicine,Meizhou 514000,China)

机构地区：[1]梅州市中医医院,514000

出　　处：《中国实用医药》2022年第6期171-173,共3页China Practical Medicine

摘　　要：目的对比右美托咪定复合异丙酚和瑞芬太尼在烧伤患者围手术期麻醉中的应用效果。方法60例烧伤需手术治疗的患者作为研究对象,随机分为实验组和对照组,每组30例。实验组患者给予右美托咪定复合异丙酚和瑞芬太尼进行麻醉,对照组患者给予异丙酚复合瑞芬太尼进行麻醉。比较两组患者不同时刻(麻醉前15 min、手术开始时、术后30 min)的平均动脉压(MAP)和心率(HR)变化情况;手术前后的C反应蛋白(CRP)和血沉(ESR)水平。结果手术开始时及术后30 min,对照组患者的MAP、HR均高于本组麻醉前15 min,且实验组患者的MAP、HR均低于对照组,差异具有统计学意义(P<0.05)。手术后,两组患者的CRP、ESR水平均较本组手术前降低,且实验组患者的CRP(8.42±6.38)mg/L、ESR(15.25±5.47)mm/h均低于对照组的(14.96±6.24)mg/L、(22.76±8.12)mm/h,差异均具有统计学意义(P<0.05)。结论右美托咪定复合异丙酚和瑞芬太尼用于烧伤手术的麻醉可减少对患者MAP和HR的影响,有效控制炎症水平,值得推广。Objective To compare the application effect of dexmedetomidine combined with propofol and remifentanil in perioperative anesthesia in burn patients.Methods A total of 60 patients with burns requiring surgical treatment were selected as the research subjects and randomly divided into the experimental group and the control group,with 30 cases in each group.The experimental group received dexmedetomidine combined with propofol and remifentanil for anesthesia,while the control group received propofol combined with remifentanil for anesthesia.Both groups were compared in terms of mean arterial pressure(MAP)and heart rate(HR)at different time points(15 min before anesthesia,at the beginning of surgery,and 30 min after surgery),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)before and after surgery.Results At the beginning of surgery and 30 min after surgery,the MAP and HR of the control group were higher than those of this group 15 min before anesthesia,and the MAP and HR of the experimental group were lower than those of the control group.All the differences were statistically significant(P<0.05).After surgery,the levels of CRP and ESR in the two groups were lower than those before surgery in this group,and the CRP(8.42±6.38)mg/L and ESR(15.25±5.47)mm/h of the experimental group were lower than(14.96±6.24)mg/L and(22.76±8.12)mm/h of the control group.All the differences were statistically significant(P<0.05).Conclusion Dexmedetomidine combined with propofol and remifentanil can reduce the impact on MAP and HR,and effectively control the level of inflammation,which is worthy of promotion.

关 键 词：右美托咪定 异丙酚 瑞芬太尼 烧伤麻醉 心率 平均动脉压 C反应蛋白 血沉 

分 类 号：R614[医药卫生—麻醉学]