解脲支原体、沙眼衣原体、淋球菌感染与盆腔炎患者不同发病状态宫颈、盆腔分泌物菌群分布的关系及优势菌敏感性抗菌药物的筛选  

Relationship between UU,CT,NG infection and distribution of cervical and pelvic secretory flora in patients with pelvic inflammatory disease at different states and antimicrobial susceptibility of dominant bacteria

作　　者：张群先[1] 梁慧娜[1] ZHANG Qunxian;LIANG Huina(Department of Clinical Laboratory,Hechi People′s Hospital,Hechi 547000,Guangxi,China)

机构地区：[1]河池市人民医院医学检验科,广西河池547000

出　　处：《中国性科学》2022年第3期97-101,共5页Chinese Journal of Human Sexuality

摘　　要：目的探讨解脲支原体(UU)、沙眼衣原体(CT)、淋球菌(NG)感染与盆腔炎患者不同发病状态宫颈、盆腔分泌物菌群分布的关系及优势菌敏感性抗菌药物的筛选。方法选取2017年2月至2020年1月河池市人民医院诊治的105例盆腔炎患者作为研究对象(观察组),进行前瞻性研究。其中轻度盆腔炎31例,中度盆腔炎42例,重度盆腔炎32例。另选取同期105例健康女性作为对照组。分析并比较观察组、对照组、不同严重程度盆腔炎患者的UU、CT、NG、分泌物菌群分布情况,分析UU、CT、NG与菌群密度、多样性以及阴道微生态情况的相关性,探讨阿奇霉素、环酯红霉素、红霉素、强力霉素、左氧氟沙星、环丙沙星、克拉霉素的药敏结果。结果观察组UU、CT、NG感染率显著高于对照组,差异具有统计学意义(P<0.05);不同严重程度盆腔炎患者UU、CT、NG感染情况比较,差异具有统计学意义(P<0.05),且随着疾病的进展,UU、CT、NG感染率呈现显著升高的趋势;观察组的阴道菌群密度Ⅰ+Ⅳ级、阴道菌群多样性Ⅰ+Ⅳ级、微生态异常比例显著高于对照组,差异具有统计学意义(P<0.05);不同严重程度盆腔炎患者阴道菌群密度Ⅰ+Ⅳ级、阴道菌群多样性Ⅰ+Ⅳ级、微生态异常比例比较,差异具有统计学意义(P<0.05);相关性分析结果显示,患者的阴道菌群密度Ⅰ+Ⅳ级、阴道菌群多样性Ⅰ+Ⅳ级以及微生态异常与UU、CT、NG感染呈正相关;盆腔炎患者药敏实验结果显示,患者对左氧氟沙星及环丙沙星的耐药率较高。结论UU、CT、NG感染与盆腔炎患者不同发病状态宫颈、盆腔分泌物菌群分布呈现显著的相关性,根据药敏学结果,建议采取克拉霉素、强力霉素进行优先治疗。Objective To study the relationship between ureaplasma urealyticum(UU),chlamydia trachomatis(CT),neisseria gonorrhoeae(NG)infection and the distribution of cervical and pelvic secretory bacteria in patients with pelvic inflammatory disease at different disease states and the susceptibility of dominant bacteria to antibiotics.Methods In this prospective study,105 cases of pelvic inflammatory disease treated in Hechi People′s Hospital from February 2017 to January 2020 were selected as the observation group,including 31 caes with mild pelvic inflammatory disease,42 cases with moderate pelvic inflammatory disease,and 32 cases with severe pelvic inflammatory disease.In addition,105 healthy women in the same period were selected as the control group.The differences in UU,CT,NG infection and the distribution of secretions microflora in the observation group and the control group and patients with different severity were analyzed respectively,and the correlation between UU,CT,NG infection and the density,diversity and vaginal microflora was analyzed.The drug sensitivity results of azithromycin,cyloxerthromycin,erythromycin,doxycycline,levofloxacin,ciprofloxacin and clarithromycin were investigated.Results The infection rates of UU,CT and NG in observation group were significantly higher than those in control group(P<0.05).There were statistically significant differences in UU,CT and NG infection among patients with different severity(P<0.05).The proportion of UU,CT and NG infection in patients showed a trend of significant increase.The vaginal flora densityⅠ+Ⅳ,vaginal flora diversityⅠ+Ⅳand the proportion of microecological abnormalities in the observation group were significantly higher than those in the control group(P<0.05).There were significant differences in the proportion of vaginal flora densityⅠ+Ⅳ,vaginal flora diversityⅠ+Ⅳand microecological abnormalities in patients with pelvic inflammatory disease of different severity(P<0.05).Correlation analysis showed that the vaginal flora densityⅠ+Ⅳ

关 键 词：解脲支原体 沙眼衣原体 淋球菌 盆腔炎 优势菌敏感性 

分 类 号：R711[医药卫生—妇产科学]