羟基磷灰石微球的制备及生物医学应用  

Preparation and biomedical application of hydroxyapatite microspheres

作　　者：王雪峰 牛小连[1,2] 秦苗 魏延 韩志军 黄棣[1,2] WANG Xuefeng;NIU Xiaolian;QIN Miao;WEI Yan;HAN Zhijun;HUANG Di(Research Center forNano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering,College of Biomedical Engineering, Taiyuan 030024, China;Institute of Biomedical Engineering, Shanxi KeyLabratory of Materials Strength & Structrual Impact,Taiyuan University of Technology, Taiyuan 030024, China)

机构地区：[1]太原理工大学生物医学工程学院生物医学工程系,纳米生物材料与再生医学研究中心,太原030024 [2]太原理工大学生物医学工程研究所,材料强度与结构冲击山西省重点实验室,太原030024

出　　处：《功能材料》2022年第3期3039-3047,共9页Journal of Functional Materials

基　　金：国家自然科学基金项目(11632013,11502158)。

摘　　要：羟基磷灰石微球具有独特的球形结构,形态规则,流动性好,比表面积大,表现出良好的生物相容性和生物活性,在生物医学领域有着广泛的应用。总结了羟基磷灰石微球的不同制备方法,如模板法、水热法、喷雾干燥法、微乳液法、沉淀法等,分析了不同制备方法对羟基磷灰石微球形貌、尺寸、结晶度等的影响,讨论了不同方法下羟基磷灰石微球形成机理。最后介绍了羟基磷灰石微球在药物缓释、骨组织修复、环境净化、生物分子分离等生物医学领域的应用进展。Hydroxyapatite microspheres have been widely used in biomedical field because of their unique spherical structure,regular morphology,good fluidity,large specific surface area,good biocompatibility and biological activity.In this paper,different preparation methods of hydroxyapatite microspheres are summarized,such as template method,hydrothermal method,spray drying method,microemulsion method,precipitation method,and so on.The effects of different preparation methods on the morphology,size and crystallinity of hydroxyapatite microspheres are analyzed.The formation mechanism of hydroxyapatite microspheres under different methods is discussed.Finally,the application progress of hydroxyapatite microspheres in biomedical fields such as drug sustained release,bone tissue repair,environmental purification and biomolecule separation is introduced.

关 键 词：羟基磷灰石微球 制备方法 微球形成原理 生物医学应用 研究进展 

分 类 号：TB34[一般工业技术—材料科学与工程]