Fe_(3)O_(4)@C纳米颗粒的界面改性及药物输运性能研究  

Fe_(3)O_(4)@C study on the interface modification and drug transport properties of nanoparticles

作　　者：曾颖怡 龙华 卫国英[1] 吴琼[1] ZENG Yingyi;LONG Hua;WEI Guoying;WU Qiong(School of Materials and Chemistry, ChinaJiliang University, Hangzhou 310018, China)

机构地区：[1]中国计量大学材料与化学学院,杭州310018

出　　处：《功能材料》2022年第3期3108-3114,共7页Journal of Functional Materials

基　　金：国家自然科学基金项目(52171083);浙江省新苗计划项目(2020R409004)。

摘　　要：Fe_(3)O_(4)纳米颗粒以其优异的磁性能,良好的生物相容性等优点,被广泛应用于药物输运系统。但是Fe_(3)O_(4)纳米颗粒表面如果不加以修饰容易发生团聚,影响其应用性能。通过水解反应包覆SiO_(2)层,再通过水热反应包覆碳层,最后刻蚀掉SiO_(2),形成了一种Fe_(3)O_(4)@C核壳结构纳米材料。采用FT-IR、TEM、紫外-可见光吸收光谱分析(UV-Vis)、振动样品磁强计(VSM)对Fe_(3)O_(4)@C纳米颗粒的结构、形貌和磁性能进行了表征分析,研究了Fe_(3)O_(4)@C纳米颗粒的界面改性及相关特性。研究结果表明这种复合界面改性的Fe_(3)O_(4)@C对Fe_(3)O_(4)的磁性能影响较小,Fe_(3)O_(4)的比表面积和药物的负载率均提升,对药物盐酸阿霉素负载率达到了98.9%。还研究了复合界面改性的Fe_(3)O_(4)@C在不同pH值环境下的药物释放行为,探究了pH值作为控释药物“开关”的可能性。Recently Fe_(3)O_(4) nanoparticles have been widely used in drug delivery systems due to their excellent magnetic properties and good biocompatibility.However,the surface of Fe_(3)O_(4) nanoparticles is prone to agglomeration if it is not modified,which will affect its application performance.In this paper,Fe_(3)O_(4) is hydrolyzed by ethyl orthosilicate(TEOS)and coated with SiO_(2) layer.Then the carbon layer is coated by hydrothermal reaction.Finally,SiO_(2) is etched by NaOH to form a kind of Fe_(3)O_(4)@C core-shell nanomaterials.The structure and morphology of Fe_(3)O_(4)@C nanoparticles were characterized by FT-IR,TEM and UV-Vis absorption spectroscopy,and the interface modification and related properties of nanoparticles are studied.The results show that the magnetic properties of Fe_(3)O_(4) are not affected by the modified Fe_(3)O_(4)@C,and the specific surface area and the loading rate of Fe_(3)O_(4) are improved.The loading rate of Fe_(3)O_(4) reaches 98.9%.The drug release behavior of the compound interface modified Fe_(3)O_(4)@C under different pH conditions is further studied to explore the possibility that pH value could be used as a'switch'for controlled drug release.

关 键 词：Fe_(3)O_(4) 纳米复合材料 药物输运 复合结构 界面改性 

分 类 号：TQ58[化学工程—精细化工]