缩孔综合征的研究进展  

Research advances of shrunken pore syndrome

作　　者：张培 周华[1] 杨敏[1] Zhang Pei;Zhuo Hua;Yang Min(Department of Nephrology,Third Affiliated Hospital,Soochow University,Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院肾内科,常州213003

出　　处：《临床肾脏病杂志》2022年第3期238-242,共5页Journal Of Clinical Nephrology

基　　金：江苏省第五期“333工程”培养资金资助项目(BRA2020156)。

摘　　要：缩孔综合征(shrunken pore syndrome,SPS)是指在排除肾外因素影响血浆胱抑素C与肌酐的前提下,基于血浆胱抑素C估算的肾小球滤过率(eGFR;)显著低于基于肌酐估算的肾小球滤过率(eGFR;)的一种病理生理状态。研究表明,SPS患者预后不良,SPS患者心血管疾病发病率和病死率很高。目前研究认为,SPS的机制可能与肾小球滤过膜孔径缩小相关,使得肾脏对相对分子质量为5~30000的分子滤过减少,并以此提出治疗方案的猜想。我们对SPS的病理生理机制、诊断、临床结局和治疗方法的研究进展进行综述,旨在提高人们对SPS的临床认识,加强对SPS的早期识别能力。As a pathophysiologic state in the absence of extrarenal influences on cystatin C or creatinine concentration,shrunken pore syndrome(SPS)occurs when estimated glomerular filtration rate(eGFR)based upon plasma cystatin C becomes significantly lower than its counterpart based upon creatinine.Studies have demonstrated that SPS patients have a poor prognosis and carry a high risk for cardiovascular morbidity and mortality.A potential mechanism of SPS is associated with a reduction of pore size of glomerular filtration membrane and a lower glomerular filtration of molecules 5~30,000.Corresponding treatment is thus proposed based upon the conjecture.This review summarized the latest researches in pathophysiological mechanism,diagnosis&treatment and clinical outcomes of SPS.It was intended to enhance its clinical awareness and boost the capability of its early identification.

关 键 词：胱抑素C 肌酐 肾小球滤过率 肾小球滤过膜 缩孔综合征 

分 类 号：R692[医药卫生—泌尿科学]