升清降浊胶囊干法制粒工艺优化及颗粒性状、填充效果分析  

Optimization of Dry Granulation Process for Shengqing Jiangzhuo Capsules(升清降浊胶囊)and Analysis of Particle Properties and Filling Effect

作　　者：黄益穗[1] 钟文嘉[1] 叶秀群 HUANG Yi-sui;ZHONG Wen-jia;YE Xiu-qun(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China)

机构地区：[1]广州中医药大学第一附属医院,广东广州510405

出　　处：《中医药导报》2022年第2期57-60,86,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广州中医药大学第一附属医院2017创新强院专项项目(2017ZWB10)。

摘　　要：目的:以升清降浊胶囊为模型,优化其干法制粒工艺参数,验证最优工艺参数和干法制粒工艺的可行性。方法:采用Box-Behnken响应面法,以压辊间隙、压辊油压、送料转速、压辊转速作为考察因素,以制得颗粒的一次成型率(Y1)作为考察指标,优化干法制粒工艺参数。结果:最优工艺参数为压辊间隙1.1 mm,压辊油压161 bar,送料转速84 r/min,压辊转速20 r/min,颗粒的一次成型率均值为52.8%,RSD为1.50%。结论:升清降浊胶囊使用干法制粒技术可行,该技术可有效提高生产效率,促进规模化生产进程。Objective:To optimize the dry granulation process parameters of Shengqing Jiangzhuo Capsules and verify the feasibility of the optimal process parameters and dry granulation process.Methods:The Box-Behnken response surface method was used to optimize the dry granulation process parameters with the roller gap,roller oil pressure,feeding speed and roller speed as the investigation factors,and the one-step forming rate(Y1)of the prepared particles as the investigation index.Results:The optimal process parameters were the roller gap of 1.1 mm,the oil pressure of the rollers of 161 bar,the feeding speed of 84 r/min,and the speed of the rollers of 20 r/min.The average one-step forming rate of particles was 52.8%,and the RSD was 1.50%.Conclusion:The dry granulation technology of Shengqing Jiangzhuo Capsules is feasible,which can effectively improve the production efficiency and promote the process of large-scale production.

关 键 词：升清降浊胶囊 Box-Behnken响应面法 干法制粒技术 一次成型率 工艺优化 

分 类 号：R283.65[医药卫生—中药学]