基于质谱快速确认新型合成大麻素5F-EDMB-PICA  

Rapid Identification of Novel Synthetic Cannabinoid 5F-EDMB-PICA by Mass Spectrometry

作　　者：袁敏 王学虎[2] 袁智伟 吴波[3] 陈慧敏 孟海涛 YUAN Min;WANG Xuehu;YUAN Zhiwei;WU Bo;CHEN Huimin;MENG Haitao(Nanjing Customs District Industrial Products Inspection Center,Nanjing,210019;Institute of Forensic Science,Jiangsu Provincial Public Security Bureau,Nanjing 210024,China;Institute of Forensic Science of Public Security Bureau of Nanjing City,Nanjing,210015;SCIEX Analytial Instrument Trading Co.,Shanghai 200335,China;Shimadzu(China)Co.,LTD.,Shanghai 200000,China)

机构地区：[1]南京海关工业产品检测中心,南京210019 [2]江苏省公安厅物证鉴定中心,南京210024 [3]南京市公安局禁毒支队毒品检验室,南京210015 [4]上海爱博才思分析仪器贸易有限公司,上海200335 [5]岛津企业管理(中国)有限公司上海分公司,上海200000

出　　处：《中国司法鉴定》2022年第2期41-45,共5页Chinese Journal of Forensic Sciences

摘　　要：目的构建一种识别合成大麻素5F-EDMB-PICA分子结构的方法。方法根据气相色谱-质谱法(GC-MS)以及谱库检索提示,对比已知物5F-MDMB-PICA的气质质谱碎片归属解析,结合液相色谱-四级杆-飞行时间质谱法(LC-Q-TOF-MS)的一级质谱拟合的分子式,推导出缴获样品烟丝内的新型合成大麻素结构,并通过文献资料得到验证。结果对一例海关查获样品烟丝进行了检验,判定其中含有合成大麻素成分5F-EDMB-PICA。结论该方法可为解析未知合成大麻素的分子结构提供新途径。Objective A method for identifying the molecular structure of synthetic cannabinoids(5F-EDMB-PICA)was established.Methods According to the GC-MS and the search of the Spectral Library,the molecular formula derived from the LC-Q-TOF-MS first-order mass spectrum of the known substance 5F-MDMB-PICA was compared and analyzed,the new structure of synthetic cannabinoids in the sample cut tobacco was obtained and verified by consulting the literature.Results A sample of cut tobacco seized by customs was determined to contain 5F-EDMB-PICA.Conclusion This method can provide a new way to resolve the structure of unknown synthetic cannabinoids.

关 键 词：合成大麻素 气相色谱-质谱法 液相色谱-四级杆-飞行时间质谱法 5F-MDMB-PICA 5F-EDMB-PICA 

分 类 号：DF795.4[医药卫生—法医学]