Screening strategies for quorum sensing inhibitors in combating bacterial infections  

作　　者：Lan Lu Mingxing Li Guojuan Yi Li Liao Qiang Cheng Jie Zhu Bin Zhang Yingying Wang Yong Chen Ming Zeng 

机构地区：[1]Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,Sichuan Industrial Institute of Antibiotics,School of Pharmacy,Chengdu University,Chengdu,610000,China [2]Laboratory of Molecular Pharmacology,Department of Pharmacology,School of Pharmacy,Southwest Medical University,Luzhou,646000,Sichuan,China

出　　处：《Journal of Pharmaceutical Analysis》2022年第1期1-14,共14页药物分析学报（英文版）

基　　金：funded by the National Natural Science Foundation of China (Grant No.: 81803812)

摘　　要：Interference with quorum sensing(QS)represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance.Over the past two decades,a novel series of studies have reported that quorum quenching approaches and the discovery of quorum sensing inhibitors(QSIs)have a strong impact on the discovery of anti-infective drugs against various types of bacteria.The discovery of QSI was demonstrated to be an appropriate strategy to expand the anti-infective therapeutic approaches to complement classical antibiotics and antimicrobial agents.For the discovery of QSIs,diverse approaches exist and develop in-step with the scale of screening as well as specific QS systems.This review highlights the latest findings in strategies and methodologies for QSI screening,involving activity-based screening with bioassays,chemical methods to seek bacterial QS pathways for QSI discovery,virtual screening for QSI screening,and other potential tools for interpreting QS signaling,which are innovative routes for future efforts to discover additional QSIs to combat bacterial infections.

关 键 词：Quorum sensing inhibitor Quorum quenching Anti-infective agent Screening strategies 

分 类 号：R446.5[医药卫生—诊断学]