Reversible regulation of enzyme-like activity of molybdenum disulfide quantum dots for colorimetric pharmaceutical analysis  

作　　者：Juan Tan Shiyue Wu Qingqing Cai Yi Wang Pu Zhang 

机构地区：[1]Engineering Research Center for Biotechnology of Active Substances,Ministry of Education,Chongqing Key Laboratory of Green Synthesis and Applications,College of Chemistry,Chongqing Normal University,Chongqing,401331,China [2]Chongqing Research Center for Pharmaceutical Engineering,College of Pharmacy,Chongqing Medical University,Chongqing,400016,China

出　　处：《Journal of Pharmaceutical Analysis》2022年第1期113-121,共9页药物分析学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.: 21775014 and 81972020);Open Foundation Project of Engineering Research Center for Biotechnology of Active Substances, Ministry of Education (Grant No.: AS201905);sponsored by the Chongqing Talent Program (Top-notch Youth);the Chongqing High-level Personnel of Special Support Program (Top-notch Youth), respectively

摘　　要：Regulating the catalytic activity of nanozymes is significant for their applications in various fields.Here,we demonstrate a new strategy to achieve reversible regulation of the nanozyme’s activity for sensing purpose.This strategy involves the use of zero-dimensional MoS;quantum dots(MQDs)as the building blocks of nanozymes which display very weak peroxidase(POD)-like activity.Interestingly,such POD-like activity of the MQDs largely enhances in the presence of Fe;while diminishes with the addition of captopril thereafter.Further investigations identify the mechanism of Fe;-mediated aggregation-induced enhancement of the POD-like activity and the inhibitory effect of captopril on the enhancement,which is highly dependent on their concentrations.Based on this finding,a colorimetric method for the detection of captopril is developed.This sensing approach exhibits the merits of simplicity,rapidness,reliability,and low cost,which has been successfully applied in quality control of captopril in pharmaceutical products.Moreover,the present sensing platform allows smartphone read-out,which has promising applications in point-of-care testing devices for clinical diagnosis and drug analysis.

关 键 词：Nanozyme Aggregation PEROXIDASE CAPTOPRIL Colorimetric detection SMARTPHONE 

分 类 号：R917[医药卫生—药物分析学]