针灸辅助治疗脓毒症胃肠功能障碍疗效Meta分析  

Meta-analysis of Therapeutic Efficiency of Acupuncture as Adjuvant Treatment on Sepsis Gastrointestinal Dysfunction

作　　者：王婷玉 孟捷[2] WANG Tingyu;MENG Jie(Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院,北京100078

出　　处：《辽宁中医药大学学报》2022年第2期165-170,共6页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：第四批全国中医优秀临床人才研修项目([2017]24号)。

摘　　要：目的系统评价针灸辅助治疗脓毒症胃肠功能障碍的临床疗效。方法对国内外5个数据库相关文献进行检索,检索时限为建库至2021年8月。采用RevMan 5.3软件进行Meta分析。结果共纳入12项随机对照试验,包括812例患者。与对照组比较,针灸辅助治疗可增加脓毒症胃肠功能障碍改善有效率[OR=3.23,95%CI(1.99,5.26),P<0.00001]及每分钟肠鸣音次数[MD=1.01,95%CI(0.83,1.19),P<0.00001],降低28 d病死率[OR=0.54,95%CI(0.31,0.96),P=0.03]、APACHE-Ⅱ评分[MD=-2.02,95%CI(-3.41,-0.63),P=0.004]、CRP水平[MD=-9.22,95%CI(-13.90,-4.55),P=0.0001]及PCT水平[MD=-1.62,95%CI(-2.77,-0.47),P=0.006],同时无更多不良反应发生。其中天枢、足三里及中脘为最常用穴位。结论在西药基础上加以针灸治疗在促进脓毒症胃肠功能障碍恢复、改善预后及减轻炎症方面具有一定的优势。Objective To systematically evaluate the efficacy of acupuncture as adjuvant treatment on sepsis gastrointestinal dysfunction.Methods We searched the pertinent literatures published before August 2021 from 5 foreign and domestic databases.RevMan 5.3 software was used for the Meta-analysis.Results Finally,12 randomized controlled trials with a total of 812 patients were included.Compared with the control group,the adjuvant treatment of acupuncture increased the effective rate of improvement in sepsis gastrointestinal dysfunction[OR=3.23,95%CI(1.99,5.26),P<0.00001]and the bowel sound times per minute[MD=1.01,95%CI(0.83,1.19),P<0.00001],and decreased the 28-day mortality rate[OR=0.54,95%CI(0.31,0.96),P=0.03],APACHE-Ⅱscores[MD=-2.02,95%CI(-3.41,-0.63),P=0.004],CRP level[MD=-9.22,95%CI(-13.90,-4.55),P=0.0001]and PCT level[MD=-1.62,95%CI(-2.77,-0.47),P=0.006],while no more adverse reactions occurred.Tianshu(ST25),Zusanli(ST36)and Zhongwan(RN12)were the most common acupoints.Conclusion Acupuncture on the basis of Western medicine has certain advantages in promoting the recovery of sepsis gastrointestinal dysfunction,improving prognosis and reducing inflammation.

关 键 词：针灸 脓毒症 胃肠功能障碍 META分析 

分 类 号：R246[医药卫生—针灸推拿学]