清热燥湿汤对小儿湿热型腹泻临床疗效、炎性因子的影响  

Effect of Qingre Zaoshi Decoction(清热燥湿汤)on Clinical Efficacy and Inflammatory Factors of Infantile Diarrhea with Damp Heat Syndrome

作　　者：郑晓枫[1] ZHENG Xiaofeng(Shenyang Children's Hospital,Shenyang 110032,Liaoning,China)

机构地区：[1]沈阳市儿童医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2022年第2期217-220,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的研究清热燥湿汤对于小儿湿热型腹泻临床疗效、血清炎性因子的影响。方法选取2017年1月—2019年1月间收治的62例湿热型腹泻患儿纳入该研究,将入选患者按随机数字法均分为常规组与中药组,常规组给予蒙脱石散及对症治疗,中药组在常规组的基础上加用医院自拟清热燥湿汤治疗;治疗1个疗程后,评估两组患儿的临床疗效,观察两组患儿治疗前、后血清炎性因子:白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)表达水平的变化情况,中医证候积分和生活质量(SF-36),统计两组患儿不良反应发生率。结果中药组总有效率为96.77%,常规组为80.65%,中药组总有效率高于常规组,临床疗效整体水平优于常规组,差异均有统计学意义(P<0.05);治疗后,两组患者血清炎性因子:IL-6、IL-10、TNF-α、hs-CRP均较本组治疗前改善,且中药组患儿表达水平均优于常规组,差异均有统计学意义(P<0.05);中药组不良反应发生率低于常规组,差异有统计学意义(P<0.05);治疗前两组患儿腹胀、腹痛和腹泻评分比较均无统计学差异(P>0.05);治疗后,两组患儿腹胀、腹痛和腹泻评分均较治疗前降低,且中药组患儿表达水平均低于常规组,差异均有统计学意义(P<0.05);治疗前两组患儿情感职能、精神健康、躯体疼痛、生命活力、生理功能、生理职能、社会功能、总体健康评分比较差异均无统计学意义(P>0.05);治疗后,两组患儿情感职能、精神健康、躯体疼痛、生命活力、生理功能、生理职能、社会功能、总体健康评分均较本组治疗前升高,且中药组患儿各项评分均显著高于常规组,差异均有统计学意义(P<0.05)。结论清热燥湿汤能够提高小儿湿热型腹泻的临床疗效,改善患儿炎性因子表达水平,促进临床症状好转,改善生活质量,且安全性高。Objective To study the effect of Qingre Zaoshi Decoction(清热燥湿汤)on the clinical efficacy and serum inflammatory factors of children with damp-heat diarrhea.Methods Sixty-two children with damp-heat type diarrhea admitted to our hospital between January 2017 and January 2019 were selected and included in this study.The selected patients were divided into routine group and traditional Chinese medicine group according to random number method,and the routine group was given Montmorillonite powder and symptomatic treatment,the traditional Chinese medicine group was treated with our hospital’s self-made Qingre Zaoshi Decoction on the basis of the conventional group;after one course of treatment,the clinical efficacy of the two groups of children was evaluated,and serum inflammatory factors:interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)expression levels of the two groups of children were observed before and after treatment the changes in TCM syndrome scores and quality of life(SF-36),the incidence of adverse reactions in the two groups of children were counted.Results The total effective rate of the traditional Chinese medicine group was 96.77%,and that of the conventional group was 80.65%.The total effective rate of the traditional Chinese medicine group was higher than that of the conventional group.The overall level of clinical efficacy was better than that of the conventional group.The difference was statistically significant(P<0.05);The serum inflammatory factors of the two groups of patients:IL-6,IL-10,TNF-α,hs-CRP were improved compared with this group before treatment,and the expression level of children in the Chinese medicine group was better than that of the conventional group,and the differences were statistically significant.Significance(P<0.05);the incidence of adverse reactions in the traditional Chinese medicine group was lower than that in the conventional group,and the difference was statistically significant(P<0.05);th

关 键 词：小儿腹泻 湿热证 炎性因子 中西医联合 

分 类 号：R442.2[医药卫生—诊断学]