坦索罗辛联合艾司西酞普兰治疗慢性非细菌性前列腺炎伴焦虑抑郁的临床研究  

Clinical Study of Tamsulosin Combined with Escitalopram in the Treatment of Chronic Abacterial Prostatitis with Anxiety and Depression

作　　者：张洪亮[1] 刘倩倩[2] 杨达宇[3] 孙景存[3] ZHANG Hongliang;LIU Qianqian;YANG Dayu;SUN Jingcun(Dept.of Urology Surgery,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Cangzhou 061001,China;Intensive Care Unit,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Cangzhou 061001,China;Dept.of Pharmacy,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Cangzhou 061001,China)

机构地区：[1]河北省沧州中西医结合医院泌尿外科,河北沧州061001 [2]河北省沧州中西医结合医院重症医学科,河北沧州061001 [3]河北省沧州中西医结合医院西药学部,河北沧州061001

出　　处：《中国医院用药评价与分析》2022年第3期323-326,331,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省2018年度医学科学研究重点课题计划项目(No.20180967)。

摘　　要：目的:探讨坦索罗辛联合艾司西酞普兰治疗慢性非细菌性前列腺炎伴焦虑抑郁的临床效果。方法:纳入2015—2019年该院收治的200例慢性非细菌性前列腺炎伴焦虑抑郁患者,根据治疗方案的不同,分为对照组与联合组,每组100例。对照组患者采用坦索罗辛联合安慰剂进行治疗,联合组患者采用坦索罗辛联合艾司西酞普兰进行治疗。比较两组患者美国国立卫生研究院-慢性前列腺炎症状指数(NIH-CPSI)量表评分、白细胞计数、卵磷脂小体数量、最大尿流率、平均尿流率、汉密尔顿抑郁量表(HAMD)评分、生活质量综合评定问卷评分和不良反应发生情况的差异。结果:对照组患者的治疗总有效率为80%(80/100),联合组患者的治疗总有效率为100%,两组的差异有统计学意义(P<0.0001)。治疗后,与对照组比较,联合组患者白细胞计数、NIH-CPSI评分的降低幅度更为明显,差异有统计学意义(P<0.01),且联合组患者的卵磷脂小体数量增多,最大尿流率、平均尿流率升高。治疗后,联合组患者的HAMD评分明显低于对照组,生活质量综合评定问卷(包括躯体疼痛、生理功能、情感职能、精神状态和社会功能)评分明显高于对照组,差异均有统计学意义(P<0.05)。联合组患者头痛、嗜睡和头晕不良反应的发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论:坦索罗辛联合艾司西酞普兰能够显著提高慢性非细菌性前列腺炎伴焦虑抑郁患者的临床治疗效果,安全可靠。OBJECTIVE:To probe into the clinical effects of tamsulosin combined with escitalopram in the treatment of chronic abacterial prostatitis with anxiety and depression.METHODS:Totally 200 patients with chronic abacterial prostatitis with anxiety and depression admitted into this hospital from 2015 to 2019 were extracted to be divided into the control group and the combined group according to different treatment regimens,with 100 cases in each group.The control group was treated with tamsulosin combined with placebo,while the combined group received tamsulosin combined with escitalopram.National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI),white blood cell count,lecithin body count,maximum urine flow rate,mean urine flow rate,Hamilton Depression Scale(HAMD)score,score of questionnaire for comprehensive assessment of quality of life and adverse drug reactions of two groups were compared.RESULTS:The total effective rate was 80%(80/100)in the control group and 100% in the combined group,and the difference was statistically significant(P<0.0001).After treatment,compared with the control group,the white blood cell count and NIH-CPSI score decreased more significantly in the combined group,with statistically significant differences(P<0.01);the lecithin body count of the combined group increased,the maximum urine flow rate and mean urine flow rate also increased.After treatment,the HAMD score of the combined group was significantly lower than that of the control group,and the scores of questionnaire for comprehensive assessment of quality of life(including physical pain,physical function,emotional function,mental state and social function)were significantly higher than that of the control group,with statistically significant differences(P<0.05).The incidences of headache,sleepiness and dizziness in the combined group were significantly lower than those in the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Tamsulosin combined with escitalopram can significantly improve the cl

关 键 词：坦索罗辛 艾司西酞普兰 慢性非细菌性前列腺炎 焦虑抑郁 临床疗效 

分 类 号：R983[医药卫生—药品] R971.43[医药卫生—药学]