瓜蒌宽肠胶囊促进妇科腹部手术患者术后胃肠功能恢复的临床研究  

Clinical Study of Gualou Kuanchang Capsules in Promoting Postoperative Gastrointestinal Function Recovery in Patients with Gynecological Abdominal Surgery

作　　者：彭丽艳 尹树旺 于桂兰[1] 阚淑月[1] 芦珊珊[1] 王春艳[1] 韩秀青[2] PENG Liyan;YIN Shuwang;YU Guilan;KAN Shuyue;LU Shanshan;WANG Chunyan;HAN Xiuqing(Dept.of Pharmacy,Tangshan Maternal and Child Health Care Hospital,Hebei Tangshan 063000,China;Dept.of Gynaecology,Tangshan Maternal and Child Health Care Hospital,Hebei Tangshan 063000,China)

机构地区：[1]唐山市妇幼保健院药剂科,河北唐山063000 [2]唐山市妇幼保健院妇科,河北唐山063000

出　　处：《中国医院用药评价与分析》2022年第3期342-344,349,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局科研计划项目(No.2019207)。

摘　　要：目的:探讨瓜蒌宽肠胶囊促进妇科腹部手术患者术后胃肠功能恢复的临床疗效。方法:选取2019年3月至2020年12月该院收治的行妇科腹部手术发生术后胃肠功能障碍的患者108例,根据信封抽签法分为对照组(54例)和研究组(54例),对照组患者给予常规治疗,研究组患者在对照组基础上联合瓜蒌宽肠胶囊治疗。治疗7 d后观察治疗效果,比较两组患者疗效、胃肠激素水平、炎症因子水平、临床指标(首次排气时间、肠鸣音恢复时间和通便时间)及不良反应发生情况的差异。结果:与对照组(77.78%,42/54)相比,研究组患者的临床总有效率(96.30%,52/54)明显更高,差异有统计学意义(P<0.05)。治疗7 d后,研究组患者胃泌素、生长抑素和胃动素水平明显高于对照组,白细胞介素6、肿瘤坏死因子α和C反应蛋白水平明显低于对照组,差异均有统计学意义(P<0.05)。研究组患者的不良反应发生率为3.70%(2/54),明显低于对照组的16.67%(9/54),差异有统计学意义(P<0.05)。研究组患者首次排气时间、肠鸣音恢复时间和通便时间明显短于对照组,差异均有统计学意义(P<0.05)。结论:瓜蒌宽肠胶囊用于妇科腹部术后,可有效降低机体炎症因子水平,改善患者胃肠功能。OBJECTIVE:To explore the clinical efficacy of Gualou Kuanchang capsules in promoting postoperative gastrointestinal function recovery in patients with gynecological abdominal surgery.METHODS:Totally 108 patients with gynecological abdominal surgery admitted into this hospital from Mar.2019 to Dec.2020 were extracted to be divided into the control group(54 cases)and the study group(54 cases)via the envelope lottery.The control group was given routine treatment,while the study group received Gualou Kuanchang capsules on the basis of the control group.The treatment effect was observed after 7 d.The efficacy,gastrointestinal hormone level,inflammatory factors,clinical indicators(first exhaust time,bowel sound recovery time and defecation time)and adverse drug reactions of two groups were compared.RESULTS:Compared with the control group(77.78%,42/54),the total clinical effective rate of the study group(96.30%,52/54)was significantly higher,and the difference was statistically significant(P<0.05).After treatment of 7 d,the levels of gastrin,somatostatin and motilin in the study group were significantly higher than those in the control group,while the levels of interleukin 6,tumor necrosis factor α and C-reactive protein were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the study group was 3.70%(2/54),significantly lower than 16.67%(9/54)in the control group,with statistically significant differences(P<0.05).The first exhaust time,bowel sound recovery time and defecation time of the study group were significantly shorter than those of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Gualou Kuanchang capsules can effectively reduce the inflammatory factors and improve the gastrointestinal function of patients after gynecologic abdominal surgery.

关 键 词：瓜蒌宽肠胶囊 妇科 腹部手术 胃肠功能 疗效 

分 类 号：R932[医药卫生—生药学]