促皮质素在肾病综合征中的作用机制  

Mechanism of adrenocorticotropic hormone in the treatment of nephrotic syndrome

作　　者：谢易[1] 王晶晶[1] 傅海东[1] 毛建华[1] Xie Yi;Wang Jingjing;Fu Haidong;Mao Jianhua(Department of Nephrology,the Children′s Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属儿童医院肾脏内科,杭州310003

出　　处：《中华实用儿科临床杂志》2022年第1期74-76,共3页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金(81770710);浙江省自然科学基金(LQ19H050007)。

摘　　要：促皮质素(ACTH)治疗某些激素抵抗型肾病综合征有一定疗效,包括膜性肾病、局灶节段性肾小球硬化、微小病变型肾病等,可有效缓解蛋白尿和保护肾功能,提示其除了促皮质素效应外,可能存在其他作用机制。现主要介绍ACTH的生物学特性,结合ACTH治疗肾病综合征的临床及基础研究,阐明其可能的作用机制,为临床应用提供依据。In recent years,it has been demonstrated in some studies that adrenocorticotropic hormone(ACTH)is effective in the treatment of certain steroid-resistant nephrotic syndrome,including membranous nephropathy,focal segmental glomerular sclerosis,minimal change nephropathy and so forth.ACTH can effectively relieve proteinuria and protect renal function,suggesting that there may be other mechanisms in addition to the adrenocorticotropic effect.This article mainly introduces the biological characteristics of ACTH,in combination with the clinical and basic studies on the treatment of nephrotic syndrome by ACTH,and clarifies several possible mechanisms,in an attempt to provide basis for clinical application.

关 键 词：促皮质素 肾病综合征 足细胞 免疫调节 

分 类 号：R692[医药卫生—泌尿科学]