细胞对机械应力的感知及其信号转导机制  

Cells respond to mechanical stress and corresponding mechanisms of signal transduction

作　　者：韦堂墙 牛超 伍季[1] 李云祥[1] 张宗平[1] 王安果[1] WEI Tangqiang;NIU Chao;WU Ji;LI Yunxiang;ZHANG Zongping;WANG Anguo(Department of Urology,Affiliated Nanchong Central Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China)

机构地区：[1]川北医学院附属南充市中心医院泌尿外科,四川南充637000

出　　处：《华西医学》2022年第3期449-452,共4页West China Medical Journal

基　　金：国家自然科学基金(81900617);南充市科技项目(18SXHZ0494)。

摘　　要：机械应力几乎调节了细胞的所有功能,探讨其如何发挥生物效应关键在于研究细胞对机械应力的感知及其信号转导机制。该文从细胞外基质、细胞膜、细胞骨架及细胞核等几个方面着手,详述了细胞对机械应力的感知及其转导机制。机械应力被细胞感知及转导主要有2个途径,一个是力的直接传递,另一个是机械信号转换为化学信号。该文旨在为研究机械应力相关疾病的精准治疗及机械应力的优化构建组织工程器官等方面提供一定参考。Mechanical stress modulates almost all functions of cells.The key to exploring its biological effects lies in studying the perception of mechanical stress and its mechanism of mechanotransduction.This article details the perception and mechanotransduction mechanism of mechanical stress by extracellular matrix,cell membrane,cytoskeleton and nucleus.There are two main pathways for the perception and mechanotransduction of mechanical stress by cells,one is the direct transmission of force,and the other is the conversion of mechanical signal into chemical signal.The purpose of this study is to provide some reference for the exploration of precise treatment of mechanical stress-related diseases and the optimization of construction of tissue engineered organs by mechanical stress.

关 键 词：机械应力 信号转导 细胞骨架 整合素 离子通道 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]