聚精汤联合硫辛酸治疗弱畸精子症的疗效观察  

Efficacy of Jujing Decoction combined with lipoic acid in the treatment of asthenospermia and teratospermia

作　　者：樊千 常凤娟 薛建国[2] 韩紫阳 孙志兴 陈赟 FAN Qian;CHANG Feng-juan;XUE Jian-guo;HAN Zi-yang;SUN Zhi-xing;CHEN Yun(Department of Andrology,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China;The First School of Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210046,China)

机构地区：[1]南京中医药大学附属医院男科,江苏南京210029 [2]南京中医药大学第一临床医学院,江苏南京210046

出　　处：《中华男科学杂志》2022年第2期157-161,共5页National Journal of Andrology

基　　金：江苏省中医药科技发展计划项目(MS2021021)。

摘　　要：目的:观察聚精汤联合硫辛酸治疗弱畸精子症的临床疗效。方法:将符合纳入标准的50例弱畸精子症患者随机分为空白对照组10例、治疗组40例,空白对照组采用生育指导,治疗组采用聚精汤联合硫辛酸治疗。治疗12周后比较两组临床疗效和精液量、精子浓度、前向运动精子(PMS)百分率、畸形精子百分率、顶体完整率、精子DNA碎片指数(DFI)、配偶妊娠情况。结果:治疗组总有效率为88.89%(32/36),配偶妊娠率8.33%(3/36),均显著高于空白对照组[10%(1/10)、0%(0/10),P<0.05]。治疗组在治疗后PMS由(21.04±6.49)%提高至(32.66±7.05)%、精子畸形率由(98.31±1.28)%降低至(96.52±1.11)%、顶体完整率由(42.18±16.67)%提高至(60.42±11.61)%、精子DFI由(21.92±6.96)%降低至(12.37±3.79)%,疗效明显优于空白对照组。结论:聚精汤联合硫辛酸能通过抗氧化应激途径明显提高患者精子活力、降低精子畸形率和DFI,提高配偶妊娠率,且具有较好的临床安全性。Objective:To observe the clinical efficacy of Jujing Decoction combined with lipoic acid in the treatment of asthenospermia and teratospermia.Methods:Fifty patients with asthenospermia and teratospermia meeting the inclusion criteria were randomly divided into a blank control(n=10)and a medication group(n=40),the former provided with fertility guidance and the latter treated with Jujing Decoction combined with lipoic acid.After 12 weeks of treatment,the clinical therapeutic effects were evaluated by comparing the semen volume,sperm concentration,percentages of progressively motile sperm(PMS)and morphologically abnormal sperm(MAS),rate of acrosome integrity,sperm DNA fragment index(DFI)and pregnancy rate between the two groups.Results:Compared with the control group,the medication group achieved a significantly higher overall effectiveness rate(10%[1/10]vs 88.89%[32/36],P<0.05)and pregnancy rate(0%[0/10]vs 8.33%[3/36],P<0.05)after treatment.The medication group also showed remarkably increased PMS from(21.04±6.49)%to(32.66±7.05)%,decreased MAS from(98.31±1.28)%to(96.52±1.11)%,elevated acrosome integrity from(42.18±16.67)%to(60.42±11.61)%,and reduced sperm DFI from(21.92±6.96)%to(12.37±3.79)%,all with statistically significant differences compared with the blank control group.Conclusion:Jujing Decoction combined with lipoic acid can significantly improve sperm motility,reduce MAS and DFI and increase the pregnancy rate through antioxidant stress,and has a high clinical safety.

关 键 词：弱精子症 畸形精子症 聚精汤 硫辛酸 氧化应激 疗效评价 

分 类 号：R698.2[医药卫生—泌尿科学]