血小板衍生生长因子-AA在骨关节炎发生发展中的作用  

The Role of Platelet-Derived Growth Factor-AA in the Pathogenesis and Development of Osteoarthritis

作　　者：徐思群 魏洁雅 谢静 周学东[1] XU Si-qun;WEI Jie-ya;XIE Jing;ZHOU Xue-dong(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Dental and Endodontic Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,成都610041

出　　处：《四川大学学报（医学版）》2022年第2期349-354,共6页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(No.81670978、No.81870754)资助。

摘　　要：骨关节炎是一种累及整个关节的慢性退行性疾病,它的发生、发展与软骨、软骨下骨、滑膜等组织的破坏及代谢异常存在密切关系。血小板衍生生长因子-AA(PDGF-AA)是包括软骨细胞、成骨细胞、破骨细胞、间充质干细胞在内的多种细胞重要的促有丝分裂和迁移的生长因子,能够有效地促进创伤修复。本文就软骨、软骨下骨、滑膜在骨关节炎的发展过程中的病理变化,以及PDGF-AA对这些组织及其相关细胞的作用研究进展做一综述。目前的研究已经基本阐明骨关节炎中软骨、软骨下骨、滑膜的基本病理变化,以及PDGF-AA对骨关节炎相关组织或细胞的重要调节作用,然而其内在机制仍不明确,如何将PDGF-AA运用于临床以及如何基于细胞来诊疗骨关节炎仍值得进一步研究。Osteoarthritis(OA)is a chronic degenerative disease involving the entire joint.The pathogenesis and progression of OA bear close connection to the destruction and the abnormal metabolism of cartilage,subchondral bones and synovium.Platelet derived growth factor-AA(PDGF-AA)is a critical mitogenic and chemotactic factor for a variety of cells,including chondrocytes,mesenchymal stem cells,osteoclasts and osteoblasts,and PDGF-AA promotes effective wound repair.This paper reviewed the pathological changes of cartilage,subchondral bones and synovium in the process of OA development,and summarized research progress regarding the effect of PDGF-AA on the tissues and related cells mentioned above.Current studies have basically clarified the pathological changes of cartilage,subchondral bones and synovium in OA patients,and have shown that PDGF-AA serves critical regulatory function in the tissues or cells involved in OA,the internal mechanism of which remains unclear,though.More studies should be done to find ways to apply PDGF-AA for clinic purpose and to diagnose and treat OA on the cellular basis.

关 键 词：骨关节炎 软骨 软骨下骨 滑膜 PDGF-AA 

分 类 号：R684.3[医药卫生—骨科学]