Modification of polyetheretherketone(PEEK)physical features to improve osteointegration  

作　　者：Dan YU Xiaoyue LEI Huiyong ZHU 

机构地区：[1]Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310003,China [2]Department of Stomatology,Zhejiang University School of Medicine,Hangzhou,310058,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第3期189-203,共15页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：This work was supported by the National Natural Science Foundation of China(No.31570989);the Young Talents Project of Zhejiang Provincial Health Department(No.2019RC151);the Zhejiang Provincial Welfare Technology Research Project(No.LGF20H140007),China.

摘　　要：Polyetheretherketone(PEEK)has been widely applied in orthopedics because of its excellent mechanical properties,radiolucency,and biocompatibility.However,the bioinertness and poor osteointegration of PEEK have greatly limited its further application.Growing evidence proves that physical factors of implants,including their architecture,surface morphology,stiffness,and mechanical stimulation,matter as much as the composition of their surface chemistry.This review focuses on the multiple strategies for the physical modification of PEEK implants through adjusting their architecture,surface morphology,and stiffness.Many research findings show that transforming the architecture and incorporating reinforcing fillers into PEEK can affect both its mechanical strength and cellular responses.Modified PEEK surfaces at the macro scale and micro/nano scale have positive effects on cell-substrate interactions.More investigations are necessary to reach consensus on the optimal design of PEEK implants and to explore the efficiency of various functional implant surfaces.Soft-tissue integration has been ignored,though evidence shows that physical modifications also improve the adhesion of soft tissue.In the future,ideal PEEK implants should have a desirable topological structure with better surface hydrophilicity and optimum surface chemistry.

关 键 词：Polyetheretherketone(PEEK) Surface topography Architecture STIFFNESS Bone integration 

分 类 号：R318.08[医药卫生—生物医学工程]