海人藻酸受体功能调节机制在脊髓痛觉敏化中的作用  

Functional regulatory mechanisms of kainate receptor in spinal hyperalgesia

作　　者：李慧莉 艾章然 王云[1] Li Huili;Ai Zhangran;Wang Yun(Department of Anesthesiology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院麻醉科,北京100020

出　　处：《国际麻醉学与复苏杂志》2022年第1期82-85,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：海人藻酸(kainate,KA)受体在中枢神经系统中广泛分布,通过调节外周和中枢感觉神经元之间的兴奋性信号参与疼痛处理。近年研究发现,多个与KA受体功能相关的蛋白在KA受体功能调节机制中发挥重要作用,从而参与伤害性疼痛信号的传递。文章通过综述KA受体特点、KA受体在疼痛通路中的表达与分布以及KA受体功能调节机制,包括与之互相作用的多种蛋白,深入探讨KA受体在神经突触可塑性和痛觉敏化中的作用。Kainate(KA)receptors are widely distributed in the central nervous system.They have a prominent effect on modulation of excitatory signaling between sensory neurons in the central nervous system and peripheral neurons.With the advances on the functional regulation mechanism of KA receptors,many interacting proteins related to the function of KA receptor have been identified playing important roles in pain signaling transmission.The discovery of these proteins opens a new door to further elucidate the role of the KA receptor in pain.This review covers the kainate receptor function,distribution in the nervous system,especially brain regions related to pain signaling transmission and its mechanism in regulation of pain sensing.In this review,the role of KA receptor in synaptic plasticity and pain sensitization is deeply discussed for understanding the functional regulation mechanism of KA receptor.

关 键 词：海人藻酸受体 痛觉敏化 突触可塑性 

分 类 号：R338[医药卫生—人体生理学]