Association between blood eosinophil count and bacterial infection and clinical outcomes in patients with severe exacerbations of chronic obstructive pulmonary disease  

作　　者：Fei Wang Luoman Yang Meng Wang Bei He 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Peking University Third Hospital,Beijing 100191,China

出　　处：《Chinese Medical Journal》2022年第4期462-464,共3页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(Nos.81670034 and 81300250)。

摘　　要：Appropriate management of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is very important because such exacerbation negatively impacts patients’health status,disease progression,and mortality.Exacerbation episodes are mainly triggered by viral and bacterial infections,and one study showed that 55%of hospitalized patients with AECOPD had a bacterial infection.[1]Some analyses have suggested that antibiotic therapy can reduce the risk of short-term mortality and improve the prognosis.However,not all patients with AECOPD benefit from antibiotic therapy.The blood eosinophil count has been used as a biomarker for eosinophil-associated airway inflammation and sepsis.However,the association between the peripheral blood eosinophil count and bacterial pathogens has not been reported.Our aim was to analyze the associations among the eosinophil count,bacterial pathogens,clinical treatments,and prognosis of patients and provide useful and comprehensive references for AECOPD management.

关 键 词：PATIENTS EXACERBATION MORTALITY 

分 类 号：R563.9[医药卫生—呼吸系统]