中医药基于氧化应激途径防治糖尿病研究机制进展  

Mechanism Progress of Traditional Chinese Medicine in Prevention and Treatment of Diabetes Based on Oxidative Stress Pathway

作　　者：王宏杨 苑天彤 张福利[1] WANG Hongyang;YUAN Tiantong;ZHANG Fuli(Heilongjiang University of Chinese Medcine,Harbin 150040,Heilongjiang,China;Nangang Branch of Heilongjiang Academy of Chinese Medical Sciences,Harbin 150001,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江省中医药科学院南岗分院,黑龙江哈尔滨150001

出　　处：《辽宁中医药大学学报》2022年第1期198-204,共7页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金(D201288,ZD201420);哈尔滨市科技创新人才研究项目(RC2017QN003081)。

摘　　要：糖尿病是一种慢性代谢性疾病,主要是由遗传、环境、饮食生活习惯等因素导致的以胰岛素分泌缺陷、胰岛功能障碍、外周组织对胰岛素敏感性下降、糖脂代谢紊乱等为主要特征的疾病。随着环境和人们生活习惯的改变,糖尿病的发病率及其相应并发症所引起的致残率、致死率正逐年增长,严重威胁着人类的健康。虽然其发病机制尚未完全明确,但目前公认氧化应激损伤是其重要的发病机制之一,研究表明中医药可通过多成分、多途径、多靶点协同作用对糖尿病进行辨证施治,从中医学角度寻求对其有效的治疗方法受到全世界的关注,该文基于氧化应激途径对中医药防治糖尿病的现状进行综述,总结整理其主要的作用机制及相关靶点、调控因子和通路,旨在为其临床应用和基础科研提供思路。Diabetes is a chronic metabolic disease,mainly caused by factors such as genetics,environment,eating habits and other factors,leading to insulin secretion defects,slet dysfunction,decreased sensitivity of peripheral tissues to insulin,and glucose and lipid metabolism disorders. With the changes in the environment and people’s living habits,the incidence of diabetes and the disability and death rates caused by its corresponding complications are increasing year by year,which is a serious threat to human health. Although its pathogenesis is not yet fully understood,it is currently recognized that oxidative stress damage is one of its important pathogenesis. Traditional Chinese medicine can treat diabetes through multiple levels,multiple channels,and multiple targets. The search for effective treatments from traditional Chinese medicine has attracted worldwide attention. This article summarizes the prevention and treatment of diabetes by traditional Chinese medicine based on the oxidative stress pathway. Organized and summarized its main mechanism and its related targets,regulatory factors and pathways. It aims to provide ideas for its clinical application and basic scientific research.

关 键 词：糖尿病 中医药 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]