单核巨噬细胞系统参与化疗引起的周围神经病理性疼痛的机制研究进展  

Research progress on the mechanism of mononuclear phagocytic system involved in chemotherapy-induced peripheral neuropathic pain

作　　者：郑翊君 刘怀存 王君[1] ZHENG Yijun;LIU Huaicun;WANG Jun(Department of Anatomy and Histology&Embryology,School of Basic Medical Sciences,Peking University,Beijing 100191,China)

机构地区：[1]北京大学基础医学院人体解剖学与组织胚胎学系,北京100191

出　　处：《中国疼痛医学杂志》2022年第2期89-97,共9页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金(81971053);北京市自然科学基金(7192089)。

摘　　要：化疗引起的周围神经病理性疼痛(chemotherapy-induced peripheral neuropathic pain,CIPNP)是以铂类和紫杉烷类为代表化疗药物的不良反应。在使用有神经毒性化疗药物后30%~40%的病人会出现CIPNP,进而影响药物的治疗效果。在引起CIPNP的诸多可能机制中,单核/巨噬细胞的作用在近年来受到广泛的关注,与之相关的受体、细胞因子和细胞分泌物都可能参与CIPNP的发生。本文从巨噬细胞表面受体的异常活化、免疫细胞的迁移和免疫活性物质的分泌几个角度总结并讨论了单核巨噬细胞系统在CIPNP中已知的可能作用机制及最新进展,有助于进一步研究下游通路和开发靶向药物。Chemotherapy-induced peripheral neuropathic pain(CIPNP)is a common dose-dependent side effect of chemotherapy drugs like platinum and taxanes.About 30%-40%of patients who use neurotoxic chemotherapy drugs will develop CIPNP,which affects the therapeutic effect.Among the possible mechanisms causing CIPNP,the role of mononuclear phagocytic system(MPS)has attracted extensive attention in recent years.The related receptors,cytokines and cell secretions may be involved in the occurrence of CIPNP.We summarized the known possible mechanism and recent progress of MPS in CIPNP from the perspectives of abnormal activation of macrophage receptors,migration of immune cells and secretion of immunoactive substances in this review,which will be helpful for further study of downstream pathways and development of targeted drugs.

关 键 词：化疗引起的周围神经病理性疼痛 单核巨噬细胞系统 趋化因子 补体 神经免疫调节 

分 类 号：R969[医药卫生—药理学]