中风Ⅱ号方联合常规治疗对缺血性脑卒中气虚血瘀证患者的临床疗效  

Clinical effects of Stroke NO.ⅡDecoction combined with conventional treatment on patients with ischemic stroke due to Qi Deficiency and Blood Stasis

作　　者：龚子崴 周凯 龙依萍 龙须 刘新春[2] 佘颜[1] 邓常清[1] GONG Zi-wei;ZHOU Kai;LONG Yi-ping;LONG Xu;LIU Xin-chun;SHE Yan;DENG Chang-qing(Laboratory for Vascular Biology,Hunan University of Chinese Medicine,Changsha 410208,China;The First Hospital Affiliated to Hunan Traditional Chinese Medical College,Zhuzhou 412000,China)

机构地区：[1]湖南中医药大学血管生物学实验室,湖南长沙410208 [2]湖南中医药高等专科学校附属第一医院,湖南株洲412000

出　　处：《中成药》2022年第3期780-784,共5页Chinese Traditional Patent Medicine

基　　金：湖南省中医药管理局重点项目(201820);湖南省教育厅科研项目(19B437)。

摘　　要：目的探讨中风Ⅱ号方联合常规治疗对缺血性脑卒中气虚血瘀证患者的临床疗效。方法100例患者随机分为对照组和观察组,每组50例,对照组给予常规治疗(阿司匹林、阿托伐他汀、苯磺酸左氨氯地平等),观察组在对照组基础上加用中风Ⅱ号方,疗程7 d。检测临床疗效、ESS评分、中医证候评分、病残/致死程度、NSE、NGF、D-D、Ang-1变化,再对NSE、D-D、Ang-1与ESS评分、中医证候评分进行相关性分析。结果观察组总有效率高于对照组(P<0.05),病残/致死程度更轻(P<0.05)。治疗后,观察组ESS评分、Ang-1升高(P<0.05),中医证候评分、NSE、D-D降低(P<0.05),较对照组更明显(P<0.05)。观察组NSE、D-D与ESS评分呈负相关(P<0.05),与中医证候评分呈正相关(P<0.05),而Ang-1恰好相反(P<0.05)。结论中风Ⅱ号方联合常规治疗对缺血性脑卒中气虚血瘀证患者临床疗效良好,可能与减轻神经元损伤、改善高凝状态、保护血管有关。AIM To explore the clinical effects of Stroke NO.Ⅱ Decoction combined with conventional treatment on patients with ischemic stroke due to Qi Deficiency and Blood Stasis. METHODS One hundred patients were randomly assigned into control group(50 cases) for 7-day intervention of conventional treatment(aspirin, atorvastatin, levamlodipine besylate, etc.), and observation group(50 cases) for 7-day intervention of both Stroke NO.Ⅱ Decoction and conventional treatment. The changes in clinical efficacy, ESS score, TCM syndrome scores, disability/mortality degree, NSE, NGF, D-D and Ang-1 were detected, after which the correlation analysis among NSE, D-D, Ang-1 and ESS score, TCM syndrome scores were performed. RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05), along with milder disability/mortality degree. After the treatment, the observation group displayed increased ESS score, Ang-1(P<0.05) and decreased TCM syndrome scores, NSE, D-D(P<0.05), which were more obvious than the control group(P<0.05). In the observation group, NSE and D-D exhibited negative correlations with ESS score(P<0.05) and positive correlations with TCM syndrome scores(P<0.05), while Ang-1 were just the contrary(P<0.05). CONCLUSION For the patients with ischemic stroke due to Qi Deficiency and Blood Stasis, Stroke NO.Ⅱ Decoction combined with conventional treatment show good clinical efficacy, which may contribute to the alleviation of neuron damage, improvement of hypercoagulability and protection of blood vessels.

关 键 词：中风Ⅱ号方 常规治疗 缺血性脑卒中 气虚血瘀 

分 类 号：R287[医药卫生—中药学]