竹灵消化学成分的研究  

Chemical constituents from Cynanchum inamoenum

作　　者：司盈盈 孙彦君[1,2] 薛贵民 赵珍珠 冯卫生 SI Ying-ying;SUN Yan-jun;XUE Gui-min;ZHAO Zhen-zhu;FENG Wei-sheng(College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南省中药开发工程技术研究中心,河南郑州450046

出　　处：《中成药》2022年第3期816-820,共5页Chinese Traditional Patent Medicine

基　　金：河南中医药大学2018年度博士科研基金(BSJJ2018-02)。

摘　　要：目的研究竹灵消Cynanchum inamoenum(Maxim.)Loes.的化学成分。方法竹灵消95%乙醇提取物采用硅胶、ODS、Sephadex LH-20、HPLC等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到14个化合物,分别鉴定为白薇苷甲(1)、山柰酚-7-O-α-L-鼠李糖苷(2)、山柰酚-3,7-O-α-L-二鼠李糖苷(3)、山柰酚-3-O-α-L-阿拉伯糖-7-O-α-L-鼠李糖苷(4)、槲皮素-3,7-O-α-L-二鼠李糖苷(5)、5-O-咖啡酰基奎宁酸丁酯(6)、(-)-丁香树脂醇(7)、(+)-丁香树脂酚-4′-O-β-D-葡萄糖苷(8)、阿魏酸(9)、对羟基桂皮酸(10)、(-)-14β-hydroxyantofine(11)、粘霉烯醇(12)、蒲公英赛醇(13)、木栓酮(14)。结论化合物2、4~6、8、10、12为首次从该属植物中分离得到,化合物3、7、9、11、13~14为首次从该植物中分离得到。AIM To study the chemical constituents from Cynanchum inamoenum(Maxim.) Loes. METHODS The 95% ethanol extract from C. inamoenum was isolated and purified by silica, ODS, Sephadex LH-20 and HPLC, then the structures of obtained compounds were identified by physicochemical properties and various spectral data.RESULTS Fourteen compounds were isolated and identified as cynatratoside A(1), kaempferol-7-O-α-L-rhamnoside(2), kaempferol-3,7-O-α-L-dirhamnoside(3), kaempferol-3-O-α-L-arabinopyranoside-7-O-α-L-rhamnopyranoside(4), quercetin-3,7-O-α-L-dirhamnoside(5), 5-O-caffeoylquinic acid butyl ester(6),(-)-syringaresinol(7),(+)-syringaresinol-4′-O-β-D-glucoside(8), ferulic acid(9), p-hydroxycinnamic acid(10),(-)-14β-hydroxyantofine(11), glutinol(12), taraxerol(13), friedelin(14). CONCLUSION Compounds 2, 4-6, 8, 10, 12 are isolated from genus Cynanchum for the first time, and compounds 3, 7, 9, 11, 13-14 are isolated from this plant for the first time.

关 键 词：竹灵消 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]