藤石松化学成分的研究  

Chemical constituents from Lycopodiastrum casuarinoides

作　　者：蒋梅香 姚晓长[1] 刘阳[1] 谭桂山[1,3] 李静[1] JIANG Mei-xiang;YAO Xiao-chang;LIU Yang;TAN Gui-shan;LI Jing(Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008,China;Hunan Traditional Chinese Medical College,Zhuzhou 412012,China;Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅医院药学部,湖南长沙410008 [2]湖南中医药高等专科学校,湖南株洲412012 [3]中南大学湘雅药学院,湖南长沙410013

出　　处：《中成药》2022年第3期821-824,共4页Chinese Traditional Patent Medicine

基　　金：湖南省自然科学青年项目(2018JJ3839);湖南省教育厅科学研究项目(19C1441)。

摘　　要：目的研究藤石松Lycopodiastrum casuarinoides(Spring)Holub的化学成分。方法藤石松75%乙醇提取物采用硅胶、半制备HPLC等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到11个化合物,分别鉴定为月桂醇(1)、4-酮松脂酚(2)、穗花杉双黄酮7,4′,7″,4-四甲基醚(3)、苜蓿素(4)、7-甲氧基苜蓿素(5)、东莨菪内酯(6)、异东莨菪内酯(7)、秦皮乙素(8)、桦木酸(9)、4-羟基苯甲醛(10)、4-羟基苯甲酸甲酯(11)。结论所有化合物均为首次从藤石松属植物中分离得到。AIM To study the chemical constituents from Lycopodiastrum casuarinoides(Spring) Holub. METHODS The 75% ethanol extract from L. casuarinoides was isolated and purified by silica and prep-HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data. RESULTS Eleven compounds were isolated and identified as lauryl alcohol(1), 4-ketopinoresinol(2), 7,4′,7″,4-tetra-O-methylamentoflavone(3), tricin(4), 7-methoxytricin(5), scopoletin(6), isoscopoletin(7), esculetin(8), betulinic acid(9), 4-hydroxybenzaldehyde(10), methyl 4-hydroxybenzoate(11). CONCLUSION All compounds are isolated from genus Lycopodiastrum for the first time.

关 键 词：藤石松 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]