非洲猪瘟病毒主要结构蛋白B细胞表位的研究现状  

Research Status on B cell Epitopes of Major Structural Proteins of African Swine Fever Virus

作　　者：栗宁 周景明 王爱萍 LI Ning;ZHOU Jing-ming;WANG Ai-ping(School of Life Science,Zhengzhou University,Zhengzhou,Henan,450001,China)

机构地区：[1]郑州大学生命科学学院,河南郑州450001

出　　处：《动物医学进展》2022年第4期93-96,共4页Progress In Veterinary Medicine

基　　金：国家重点研发计划项目(2021YFD1801301);“中原千人计划”-中原科技创新领军人才项目(204200510005)。

摘　　要：非洲猪瘟(ASF)是猪的一种烈性病毒病,病死率可达100%。ASF的肆虐,给全球养猪业造成了巨大的经济损失。ASF的防控依旧是世界性难题,目前尚无有效的疫苗可用,ASF的有效诊断对于该病的防控显得至关重要。该病的致病病原是非洲猪瘟病毒(African swine fever virus, ASFV),病毒表位信息是诊断试剂和疫苗的研发基础,论文对ASFV病毒蛋白p72、p30、p54蛋白B细胞表位的研究现状进行概述,了解表位的研究现状有助于ASFV感染机制的研究,同时有助于新型检测试剂及疫苗的研发。African swine fever(ASF)is a severe viral disease of pigs with a mortality of 100%.The spread of ASF has caused huge economic losses to the global pig industry.The prevention and control of ASF is still a worldwide problem,and there is no effective vaccine available at present.The effective diagnosis of ASF is very important for the prevention and control of the epidemics.African swine fever virus(ASFV)is the pathogenic agent of ASF.The information of the epitopes located on the virus is the basis for the research and development of diagnostic reagents and vaccines.Here,the research progress of B cell epitopes on p72,p30and p54proteins of ASFV is summarized.It is helpful for the study of ASFV infection mechanism and the development of new detection reagents and vaccines.

关 键 词：非洲猪瘟病毒 结构蛋白 B细胞表位 

分 类 号：S852.65[农业科学—基础兽医学] S858.28[农业科学—兽医学]