单中心就诊2~18岁儿童胆固醇水平异常发生率及病因分析  

Incidence and cause of abnormal cholesterol in children aged 2-18 years in a single center

作　　者：闫辉[1] 逄璐 李雪迎[3] 杨文双[2] 蒋世菊[2] 刘平[1] 闫存玲[2] YAN Hui;PANG Lu;LI Xue-ying;YANG Wen-shuang;JIANG Shi-ju;LIU Ping;YAN Cun-ling(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China;Department of Laboratory,Peking University First Hospital,Beijing 100034,China;Department of Statistics,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院儿科,北京100034 [2]北京大学第一医院检验科,北京100034 [3]北京大学第一医院医学统计室,北京100034

出　　处：《北京大学学报（医学版）》2022年第2期217-221,共5页Journal of Peking University:Health Sciences

摘　　要：目的:探讨单中心就诊患儿血浆胆固醇水平异常情况及分布规律。方法:回顾性分析2016年6月至2019年6月在北京大学第一医院有胆固醇检测结果的2~18岁儿童血浆胆固醇水平。总胆固醇(total cholesterol,TC)采用胆固醇氧化酶法,低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)采用清除法检测,计数资料比较应用卡方检验。结果:调查有效数据11829例,其中男性7087例,女性4742例。TC升高儿童1822例(15.4%),LDL-C升高儿童1371例(11.6%),HDL-C降低儿童2798例(23.7%),胆固醇水平异常儿童总和4427例(37.4%)。非常见继发性高脂血症病因就诊儿童7835人,其中TC升高儿童731例(9.3%),LDL-C升高儿童561例(7.2%),HDL-C降低儿童1886例(24.1%),胆固醇水平异常儿童总和2576例(32.9%)。不同疾病就诊儿童中,胆固醇异常发生率差异有统计学意义(P<0.05)。TC升高及LDL-C升高发生率的前三位主要就诊原因均分别为“血脂异常”“泌尿系统疾病”“营养性疾病”。除小儿内科外,其他科室送检的1257例患儿血脂检测样本中,300例存在胆固醇水平异常(23.8%),其中高胆固醇血症患儿70例(5.6%),高低密度脂蛋白血症患儿44例(3.5%),低高密度脂蛋白血症患儿224例(17.8%)。在非常见继发性高脂血症病因就诊儿童中,因LDL-C≥140 mg/dL(3.6 mmol/L)需要进一步排除家族性高胆固醇血症的患儿共365例,占该部分患儿的4.6%。结论:就诊儿童胆固醇异常发生率高,在原发病诊治的同时加强胆固醇管理不仅有助于控制继发性高胆固醇血症,也为及时发现家族性高胆固醇血症提供可能。Objective:To investigate the abnormality and distribution of plasma cholesterol levels in single-center hospitalized children.Methods:The blood lipid levels of children aged 2-18 years who had blood lipid test results in Peking University First Hospital from June 2016 to June 2019 were etrospectively analyzed.Cholesterol oxidase method was used for total cholesterol,and high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were detected by clearance method.The counting data were compared with chi-square test.Results:The survey had involved 11829 children(7087 were boys and 4742 were girls).1822(15.4%)children were with elevated total cholesterol,1371(11.6%)children with elevated low-density lipoprotein cholesterol,and 2798(23.7%)children with high-density lipoprotein cholesterol reduction.The total number of the children with abnormal cholesterol levels was 4427(37.4%).Among the 7835 children who visited hospital due to the disease not commonly inducing dyslipidemia,731(9.3%)had elevated TC,561(7.2%)had elevated LDL-C,1886(24.1%)had decreased HDL-C,and 2576(32.9%)had abnormal cholesterol levels.Among the children with different diseases,the difference in the incidence of abnormal cholesterol was statistically significant.The top three main groups of the children with increased total cholesterol and low-density lipoprotein cholesterol were“dyslipidemia”,“urinary tract disease”,and“nutritional disease”;The top three main groups of the children with reduced high-density lipoprotein cholesterol were“respiratory diseases”,“dyslipidemia”,“hematological diseases and malignant tumors”.Among the 1257 blood li-pid test results sent by other departments,300 cases had abnormal cholesterol levels(23.8%).Among them,there were 70 children with hypercholesterolemia(5.6%),44 children with increased low-density lipoprotein cholesterol(3.5%),and 224 children with reduced high-density lipoprotein cholesterol(17.8%).There were 365(4.6%)children with low-density lipoprotein cholesterol≥

关 键 词：高胆固醇血症 血脂异常 监测 儿童 

分 类 号：R725.4[医药卫生—儿科]