miR-146a在慢阻肺患者中的表达及其意义  

Expression and significance of miR-146a in COPD patients

作　　者：张星星[1,3] 杨勤军 王小乐 高雅婷[2,3] 王胜 孙泰[1] 李泽庚 ZHANG Xingxing;YANG Qinjun;WANG Xiaole;GAO Yating;WANG Sheng;SUN Tai;LI Zegeng(The First Affiliated Hospital of Anhui University of Chinese Medicine Anhui Hefei 230031,China;Anhui University of Chinese Medicine Anhui Hefei 230032,China;Institute of Respiratory Disease,Anhui Academy of Chinese Medicine Anhui Hefei 230031,China)

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031 [2]安徽中医药大学,安徽合肥230032 [3]安徽省中医药科学院中医呼吸病防治研究所,安徽合肥230031

出　　处：《中医药临床杂志》2022年第2期361-363,共3页Clinical Journal of Traditional Chinese Medicine

基　　金：安徽省自然科学基金面上项目(1908085MH288);基于云数据的慢性阻塞性肺疾病综合管理平台开发及中医特色技术推广研究(201903a07020015);安徽省教育厅中医药防治肺系重大疾病重点实验室(皖教秘科[2019]9号)。

摘　　要：目的:探讨miR-146a在慢阻肺患者血清中的表达及其临床意义。方法:收集该院慢阻肺患者40例设为慢阻肺组,体检中心正常人20例设为正常对照组,RT-qPCR法检测两组血清中miR-146a的表达水平。结果:慢阻肺组血清中的miR-146a相对表达量低于正常对照组,差异均具有统计学意义(P<0.05)。结论:miR-146a在慢阻肺血清中呈现低水平表达,可能是其抗炎作用减弱致慢阻肺进展的机制之一。Objective:To investigate the expression and clinical significance of miR-146a in serum of patients with chronic obstructive pulmonary disease.Methods:A total of 40 patients with COPD in our hospital were collected as the COPD group,and 20 normal people in the physical examination center were selected as the normal control group.The expression levels of miR-146a in the serum of the two groups were detected by RT-qPCR.Results:The relative expression of miR-146a in serum of COPD group was lower than that of normal control group,and the difference was statistically significant(P<0.05).Conclusion:miR-146a is expressed at a low level in COPD serum,which may be one of the mechanisms of COPD progression due to its weakened anti-inflammatory effect.

关 键 词：慢性阻塞性肺疾病 MIR-146A 临床研究 

分 类 号：R563[医药卫生—呼吸系统]