Simulation and prediction of membrane fusion dynamics  

作　　者：Zhi Zheng Shouqin Lü Mian Long 

机构地区：[1]Center of Biomechanics and Bioengineering,Key Laboratory of Microgravity(National Microgravity Laboratory),Beijing Key Laboratory of Engineered Construction and Mechanobiology,and CAS Center for Excellence in Complex System Mechanics,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China [2]School of Engineering Science,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Theoretical & Applied Mechanics Letters》2022年第1期49-55,共7页力学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Grants 32130061 and 12172366)。

摘　　要：Membrane fusion is an important process by which biological membranes perform their life activities. Simulations show that the membrane fusion process happens mainly through three pathways, where the Stalk-Pore hypothesis, in which two membranes come into close contact to form a stalk to a hemifusion intermediate, and then the fusion pore opens to achieve completely fusion, is widely accepted, and there exist two free energy barriers that break the current structural steady state for lipid rearrangement. Factors of lipid composition, mechanical environment, protein and ion have regulatory roles in the membrane fusion process by effecting membrane curvature structurally and the free energy barriers from energetic perspective. Meanwhile, many theoretical models, represented by the Helfrich model, have been proposed to predict the membrane fusion process. In this paper, we review the research process of membrane fusion and mainly introduce the dynamics of membrane fusion, regulation factors and typical theoretical models.

关 键 词：Membrane fusion Hemifusion intermediates Fusion pathway REGULATION Helfrich model 

分 类 号：Q81[生物学—生物工程]