rTMS结合认知行为治疗对吗啡依赖患者特质冲动、突显网络功能的影响  

Effects of rTMS Combined with Cognitive Behavioral Therapy on Trait Impulsivity and Salience Network Function in Morphine-Dependent Patients

作　　者：李建平 曾莞勇 杜维豪 陈江永 Li Jianping(Guangzhou Baiyun Mental Hospital,Guangzhou 510000)

机构地区：[1]广州白云心理医院,广东广州510000

出　　处：《黑龙江医药》2022年第2期249-252,共4页Heilongjiang Medicine journal

基　　金：中国生物技术发展中心科研项目(项目编号:2018YFC1314400)。

摘　　要：目的:分析重复经颅磁刺激(rTMS)结合认知行为治疗对吗啡依赖患者特质冲动、突显网络功能的影响。方法:选取我院吗啡依赖患者64例,根据治疗方法分组,各32例,两组均给予美沙酮治疗,在此基础上常规组采取认知行为治疗,研究组采取rTMS联合认知行为治疗。比较2组疗效、治疗前后贝克抑郁量表21项版(BDI-21)、药物成瘾者生命质量测定量表(QOL-DA)、Barratt冲动评估量表-11(BIS-11)评分及突显网络功能变化。结果:2组总有效率比较,研究组为93.75%,高于常规组(75.00%),P<0.05;治疗后2组BDI-21、QOL-DA、BIS-11评分均明显改善,研究组改善幅度更明显(P<0.05);治疗后2组双侧背内侧前额叶、双侧楔前叶、左侧中央后回、左侧枕下回功能连接值明显下降,研究组下降程度更明显(P<0.05)。结论:rTMS联合认知行为治疗能明显改善吗啡依赖患者突显网络功能,降低特质冲动水平,减轻抑郁情绪,提高生命质量。Objective:To analyze the effects of repeated transcranial magnetic stimulation(rTMS)combined with cognitive behavioral therapy on trait impulsivity and salience network function in morphine-dependent patients.Methods:64 cases of morphine-dependent patients in our hospital were selected and divided into two groups according to the treatment method,32 cases in each group.Both groups were given methadone treatment.On this basis,the conventional group received cognitive behavioral therapy,and the research group received rTMS combined with cognitive behavioral therapy.Efficacy,beck Depression Scale 21(BDI-21),Quality of Life Scale for Drug Addicts(QOL-DA),Barratt Impulse Assessment Scale 11(BIS-11)scores before and after treatment were compared between the two groups.Results:The total effective rate of the study group was 93.75%,higher than that of the conventional group(75.00%),P<0.05.After treatment,bDI-21,QOL-DA and BIS-11 scores were significantly improved in the 2 groups,and the improvement was more obvious in the research group(P<0.05).After treatment,the functional connection values of bilateral dorsomedial prefrontal lobe,bilateral precuneus,left posterior central gyrus and left inferior occipital gyrus decreased significantly in the two groups,and the decrease degree was more obvious in the study group(P<0.05).Conclusion:rTMS combined with cognitive behavioral therapy can significantly improve the salience network function,reduce the trait impulse level,alleviate depression and improve the quality of life in morphine-dependent patients.

关 键 词：重复经颅磁刺激 认知行为治疗 吗啡依赖 突显网络功能 特质冲动水平 

分 类 号：R996[医药卫生—毒理学] R749.6[医药卫生—药学]