区域环境因素对健康成年人中性粒细胞与淋巴细胞比值参考值的响应  

Responses of regional environmental factors to the reference value of neutrophil-lymphocyte ratio in healthy adults

作　　者：李佳鑫 葛淼 张雷 裴泽华 杨文婕 何进伟[2] 王聪霞[3] LI Jiaxin;GE Miao;ZHANG Lei;PEI Zehua;YANG Wenjie;HE Jinwei;WANG Congxia(Institute of Health Geography,School of Geography and Tourism of Shaanxi Normal University,Xi’an 710061;Medical College of Yan’an University,Yan’an 716099;The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710054,China)

机构地区：[1]陕西师范大学地理科学与旅游学院健康地理研究所,陕西西安710061 [2]延安大学医学院,陕西延安716099 [3]西安交通大学第二附属医院,陕西西安710054

出　　处：《西安交通大学学报（医学版）》2022年第2期302-308,共7页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.41761100)。

摘　　要：目的对可能影响全国健康成年人中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)参考值空间分异的影响因子进行筛选,探究在全国范围内NLR参考值的变化趋势。方法收集全国62个城市的162681名健康成年人的NLR参考值,Spearman回归法分析NLR与25个地理因素二级指标的相关性,提取出9个具有显著相关关系的地理因素,构建随机森林模型,预测全国城市的健康成年人NLR参考值,并采用析取克里金的方法绘制全国健康成年人的NLR参考值地理分布图。结果海拔、年日照时数、年平均气温、年平均相对湿度、气温年较差、年平均风速、表土有机质含量、表土(粘土)阳离子交换量、土壤CaSO4总量这9项二级指标的差异性显著影响全国健康人NLR参考值分布差异性。全国健康成年人NLR参考值的空间分布呈现差异性,表现为东南高、西北低,沿海高、内陆低的变化态势。结论本研究为后续进一步研究不同影响因子对NLR指标参考值的作用机制奠定了基础。建立显著影响因素构成的随机森林模型,在不同地区使用NLR参考值作为新型冠状病毒预后因子制定参考标准时提供依据。Objective This paper screened the factors that may influence the spatial differentiation of Neutrophil-tolymphocyte ratio(NLR)reference values in healthy adults in China and explored the trend of NLR reference values in China.Methods For this research,we collected the NLR of 162681 healthy adults from 62 cities in China.Spearman regression analysis was used to analyze the correlation between NLR and 25 geography secondary indexes.We extracted 9 indexes with significant correlation,built a random forest(RF)model,and predicted the country’s urban healthy adults’NLR reference value.By using the disjunctive Kriging method,we obtained the geographical distribution of NLR reference value of healthy adults in China.Results The reference value of NLR of healthy adults in China was significantly correlated with the 9 secondary indexes,namely,altitude,sunshine duration,annual average temperature,annual average relative humidity,annual temperature range,annual average wind speed,content of organic matter in topsoil,cation exchange capacity in topsoil(clay),and total amount of CaSO4 in soil.The geographical distribution of NLR values of healthy adults in China showed a trend of being higher in Southeast China and lower in Northwest China,higher in coastal areas and lower in inland areas.Conclusion This study lays a foundation for further research on the mechanism of different influencing factors on the reference value of NLR index.A random forest model composed of significant influencing factors has been established to provide the basis for formulating reference criteria for the prognostic factors of the novel coronavirus using NLR reference values in different regions.

关 键 词：新冠肺炎 NLR 自然环境 随机森林 析取克里金 

分 类 号：R188.2[医药卫生—流行病学] R188.7[医药卫生—公共卫生与预防医学]