护骨素、胎球蛋白A与慢性肾脏病患者腹主动脉钙化的相关研究  

Study on the relationship between serum OPG and fetuin-A with abdominal aortic calcification in patients with chronic kidney Disease

作　　者：代云 陈卫东 刘磊[1] 吴雪平[1] DAI Yun;CHEN Weidong;LIU Lei(Department of Nephrology,Bengbu Medical College First Affiliated Hospital,Bengbu,233000)

机构地区：[1]蚌埠医学院第一附属医院肾病科,蚌埠233000

出　　处：《中国中西医结合肾病杂志》2022年第1期16-19,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：蚌埠医学院自然科学类项目(No.BYKY1775)。

摘　　要：目的:探讨慢性肾脏病(CKD)3~5D期患者腹主动脉钙化(AAC)与血清OPG、Fetuin-A的相关性,并分析AAC的危险因素。方法:选取95例CKD3~5D期患者为实验组,同时选取64例健康人作为对照组比较一般临床资料,均采用腹部侧位X线片评估腹主动脉钙化情况,并计算钙化积分;ELISA法检测OPG、Fetuin-A水平。结果:实验组中AAC组52例,non-AAC组43例,实验组OPG水平高于对照组、实验组Fetuin-A水平低于对照组,差异有统计学意义(P<0.05);AAC组OPG水平高于non-AAC组,AAC组Fetuin-A水平低于non-AAC组,差异有统计学意义(P<0.05);OPG与年龄、AAC成正相关,Fetuin-A与AAC呈负相关,Logistic回归分析发现年龄、磷、OPG、Fetuin-A是AAC的危险因素;OPG是AAC严重程度分级的危险因素。结论:CKD患者腹主动脉钙化发生率高,年龄、磷、OPG、Fetuin-A是AAC的危险因素,OPG是区分AAC严重程度的独立危险因素。Objective:To research the correlation between abdominal aortic calcification(AAC) and serum OPG and Fetuin-A in patients with chronic kidney disease(CKD) at stage 3-5, and to analyze the risk factors of AAC. Methods:95 patients with CKD3-5 D stage were selected as the experimental group, and 64 healthy subjects at the same period were selected as the control group to compare the general clinical data. Abdominal lateral X-ray was used to evaluate AAC, and calcification score was calculated, and OPG and Fetuin-A levels were detected by ELISA. Results:In the experimental group, 52 cases in AAC group and 43 cases in non-AAC group, OPG level in the experimental group was higher than that in the control group, while fetuin-A level in the experimental group was lower than that in the control group, the difference was statistically significant differences(P<0.05), OPG in AAC group was higher than that in non-AAC group, fetuin-A in AAC group was lower than that in non-AAC group, the difference was statistically significant(P<0.05);OPG was positively correlated with age and AAC, while Fetuin-A was negatively correlated with AAC. Logistic regression analysis showed that age, phosphorus, OPG and Fetuin-A were risk factors for AAC, while OPG was a risk factor for severity grading of AAC. Conclusion:The incidence of abdominal aortic calcification is high in patients with CKD. Age, phosphorus, serum OPG and Fetuin-A were risk factors for AAC, and OPG was an independent risk factor to distinguish the severity of AAC.

关 键 词：慢性肾脏病 腹主动脉钙化 护骨素 胎球蛋白A 

分 类 号：R692[医药卫生—泌尿科学]