新型冠状病毒肺炎患者血清白蛋白水平与患者病情的相关分析  

Correlation between serum albumin level and severity in COVID-19 patients

作　　者：林友飞[1] 王姣焦 吴迪[1] 刘毅萍 陈晓红[1] 陈力舟[1] Lin Youfei;Wang Jiaojiao;Wu Di;Liu Yiping;Chen Xiaohong;Chen Lizhou(Department of Tuberculosis,Fuzhou Pulmonary Hospital of Fujian Province,Clinical Teaching Hospital of Fujian Medical University,Fuzhou 350008,China)

机构地区：[1]福建省福州肺科医院福建医科大学临床教学医院结核科,福州350008

出　　处：《国际医药卫生导报》2022年第8期1107-1111,共5页International Medicine and Health Guidance News

基　　金：福州市科技计划项目(2020-XG-023、2020-XG-024)。

摘　　要：目的探讨新型冠状病毒肺炎(coronavirusdisease 2019,COVID-19)患者血清白蛋白水平与患者病情的关系。方法回顾性分析2020年1月23日至3月5日期间福建省福州肺科医院出院的70例COVID-19患者临床资料,按血清白蛋白水平将患者分为正常白蛋白组(43例)和低蛋白血症组(27例)。统计分析两组患者入院后第1、7、14天血清白蛋白水平和胸部影像学评分以及核酸转阴时间。计量资料组间比较采用独立样本t检验,计数资料组间比较采用χ^(2)检验或Fisher确切概率法。结果70例患者中,男36例、女34例,年龄(43.53±14.91)岁。与正常白蛋白组相比,低蛋白血症组患者的年龄更大(t=3.117,P=0.003),患基础疾病(χ^(2)=9.807,P=0.002)和出现咳嗽(χ^(2)=7.396,P=0.007)的比例更高。低蛋白血症组患者第1天、第7天、第14天的血清白蛋白水平分别为(39.66±3.77)g/L、(32.58±4.00)g/L、(36.20±2.27)g/L,均低于正常白蛋白组的(43.55±5.67)g/L、(41.18±6.16)g/L、(41.82±4.87)g/L,差异均有统计学意义(均P<0.05)。低蛋白血症组患者第1天、第7天、第14天的胸部影像学评分分别为(6.88±2.80)分、(6.57±2.98)分、(4.88±2.47)分,均高于正常白蛋白组的(4.85±2.76)分、(4.58±3.21)分、(3.45±1.74)分,差异均有统计学意义(均P<0.05)。低蛋白血症组患者核酸转阴时间为(22.68±4.60)d,长于正常白蛋白组(19.50±5.36)d,差异有统计学意义(t=-2.329,P=0.023)。结论COVID-19患者血清白蛋白水平与患者的病情密切相关,患者血清白蛋白水平越低,胸部影像更严重,核酸转阴时间更长。Objective To investigate the relationship between serum albumin level and severity in patients with coronavirus disease 2019(COVID-19).Methods The clinical data of 70 COVID-19 patients in Fuzhou Pulmonary Hospital of Fujian Province from January 23,2020 to March 5,2020 were analyzed retrospectively.According to the initial serum albumin level,the enrolled patients were divided into a normal albumin group(43 cases)and a hypoalbuminemia group(27 cases).Then,the differences in both groups were analyzed about serum albumin levels and chest imaging scores on the 1st,7th,and 14th day after admission,as well as nucleic acid turning negative time.Independent sample t test was used to compare the measurement data between groups,andχ^(2) test or Fisher's exact probability method was used to compare the count data between groups.Results Among the 70 patients,36 were male and 34 were female,aged(43.53±14.91)years.The patients in the hypoalbuminemia group were older(t=3.117,P=0.003)and had a higher incidence of underlying diseases(χ^(2)=9.807,P=0.002)and cough(χ^(2)=7.396,P=0.007)than those in the normal albumin group.The serum albumin levels in the hypoalbuminemia group were(39.66±3.77)g/L,(32.58±4.00)g/L,and(36.20±2.27)g/L on the 1st,7th,and 14th day after admission,which were lower than those in the normal albumin group[(43.55±5.67)g/L,(41.18±6.16)g/L,and(41.82±4.87)g/L],with statistically significant differences(all P<0.05).The chest imaging scores in the hypoalbuminemia group were(6.88±2.80)points,(6.57±2.98)points,and(4.88±2.47)points on the 1st,7th,and 14th day after admission,which were higher than those in the normal albumin group[(4.85±2.76)points,(4.58±3.21)points,and(3.45±1.74)points],with statistically significant differences(all P<0.05).The nucleic acid turning negative time in the hypoalbuminemia group was(22.68±4.60)d,longer than that in the normal albumin group[(19.50±5.36)d],with a statistically significant difference(t=-2.329,P=0.023).Conclusions The serum albumin level in COVID-19 patient

关 键 词：新型冠状病毒肺炎 低蛋白血症 严重急性呼吸综合征冠状病毒2 

分 类 号：R563.1[医药卫生—呼吸系统]