荨麻皮刺水提液对小鼠离体肠平滑肌运动的影响  

Effects of Aqueous Extract of Urtica Prickle on the Motility of Isolated Intestinal Smooth Muscle in Mice

作　　者：蔡鹏 孙小燕 阿迪莱·艾力 雷艳 单宝轩 赵红琼[1] CAI Peng;SUN Xiaoyan;Adilai Ali;LEI Yan;SHAN Baoxuan;ZHAO Hongqiong(College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052, China)

机构地区：[1]新疆农业大学动物医学学院,乌鲁木齐830052

出　　处：《新疆农业科学》2022年第3期767-773,共7页Xinjiang Agricultural Sciences

基　　金：新疆维吾尔自治区自然科学基金(2016D01A030)。

摘　　要：【目的】研究荨麻促进消化道平滑肌运动的植株主要部位,分析其可能的受体机制。【方法】用生物信号处理系统监测麻叶荨麻皮刺与内茎(不含皮刺)水提液对小鼠离体小肠平滑肌的影响。【结果】2倍浓度递增(0.1%~3.2%)的皮刺剂量依赖性增加小肠收缩幅度、收缩张力和收缩峰值(P<0.05),但对收缩频率无影响(P>0.05);而内茎浓度达0.4%后使小肠收缩频率减慢(P<0.05)。0.8%皮刺一次性用药后小肠收缩幅度、收缩张力、收缩峰值均显著升高(P<0.05),而同剂量内茎对小肠收缩无影响(P>0.05)。M-受体阻断剂ATr与0.8%皮刺联合用药可使收缩幅度显著减弱(P<0.05)。【结论】荨麻植株的皮刺对消化道平滑肌具有促进作用,且可能部分作用是通过激活M-受体而实现。【Objective】The purpose of this study aims to test the main parts of urtica simulating smooth muscle movement,and to explore its possible receptor mechanism.【Methods】The biological signal processing system was used to monitor the effects of aqueous extract from urtica prickle or inner stem(without prickle)on the isolated small intestinal smooth muscle of mice.【Results】A 2-fold increasing concentration(0.1%-3.2%)of prickles increased the intestinal contract amplitude,tension and peak in a dose-dependent manner(P<0.05),but had no effect on contract frequency(P>0.05);When the concentration of inner stem reached 0.4%,the contract frequency of the small intestine was reduced(P<0.05).The contract amplitude,tension,and peak of the small intestine were significantly increased(P<0.05)after 0.8%prickle administration,but the same dose of inner stem had no effect on the small intestine contraction(P>0.05).The combination of M-receptor blocker ATr and 0.8%prickle significantly reduced the contraction(P<0.05).【Conclusion】The prickle of urtica can promote the smooth muscle of the digestive tract,and the effect may be partly achieved by activating M-receptors.

关 键 词：麻叶荨麻 小鼠 小肠 平滑肌 M-受体 皮刺 

分 类 号：S811.2[农业科学—畜牧学]