低分子肝素与小剂量硫酸镁对早发型重度子痫前期的影响  

Effects of Low Molecular Weight Heparin and Low-dose Magnesium Sulfate on Early-onset Severe Preeclampsia

作　　者：单丝洁 SHAN Sijie(Department of Obstetrics,Luoding Maternal and Child Health Hospital,Luoding Guangdong 527200,China)

机构地区：[1]罗定市妇幼保健院产科,广东罗定527200

出　　处：《中国卫生标准管理》2022年第5期89-92,共4页China Health Standard Management

摘　　要：目的 分析早发型重症子痫前期患者接受低分子肝素联合小剂量硫酸镁治疗产生的应用效果。方法 在2019年12月—2020年12月随机纳入88例早发型重症子痫前期患者作为研究对象,经过电脑随机分组的方式将患者平均纳入对比组和试验组,每组各44例,对比组应用的治疗方法为硫酸镁单一治疗,试验组应用的治疗方法为低分子肝素+硫酸镁联合治疗,针对两组治疗效果进行比较分析。结果 试验组FBG、收缩压以及舒张压水平在治疗后明显较对比组更低,差异有统计学意义(P <0.05);试验组TT、PT以及APTT指标在治疗后均较对比组显著更高,差异有统计学意义(P <0.05);试验组新生儿不良事件发生率以及患者并发症发生率均较对比组明显更低,组间差异有统计学意义(P <0.05)。结论 通过将低分子肝素与小剂量硫酸镁联合治疗,能够对早发型重症子痫前期患者临床各项指标的改善起到积极作用,同时对降低新生儿不良事件发生、患者并发症的发生具有重要价值和意义,应当在临床中大力推广应用。Objective To analyze the application effect of low molecular weight heparin combined with low-dose magnesium sulfate in the treatment of early-onset severe preeclampsia. Methods From December 2019 to December 2020, a total of 88 patients with earlyonset severe preeclampsia were randomly selected as the research objects. The patients were randomly divided into the control group and the experimental group by computer, with 44 cases in each group. The treatment method of the control group was magnesium sulfate single treatment, and the treatment method of the experimental group was low molecular weight heparin + magnesium sulfate combined treatment.The therapeutic effects of the two groups were compared and analyzed.Results The levels of FBG, systolic blood pressure and diastolic blood pressure in the test group were significantly lower than those in the control group after treatment, and the difference was statistically significant(P < 0.05);the TT, PT and APTT indexes of the test group were significantly higher than those in the control group after treatment.The difference was statistically significant(P < 0.05);the incidence of neonatal adverse events and the incidence of complications in the experimental group are significantly lower than those of the control group, and the difference was statistically significant(P < 0.05).Conclusion Low molecular weight heparin combined with small dose of magnesium sulfate can play a positive role in the improvement of clinical indicators of patients with early-onset severe preeclampsia,and has important value and significance in reducing the occurrence of neonatal adverse events and complications, which should be vigorously promoted in clinical application.

关 键 词：低分子肝素 小剂量 硫酸镁 早发型重度子痫前期 临床效果 不良事件 

分 类 号：R714[医药卫生—妇产科学]