mTOR信号通路调控自噬在脊髓损伤中的作用研究进展  

Research advances on the role of mTOR signaling pathway in regulating autophagy in spinal cord injury

作　　者：周付瑶 陈威克 赵国栋 孔令胜[2] Zhou Fuyao;Chen Weike;Zhao Guodong;Kong Lingsheng(Jining Medical College Clinical School,Jining 272067,China;Department of Neurosurgery,Affiliated Hospital of Jining Medical College and Shandong Provincial Key Laboratory of Stem Cell and Neurooncology,Jining 272067,China)

机构地区：[1]济宁医学院临床医学院,济宁272067 [2]济宁医学院附属医院神经外科暨山东省干细胞与神经肿瘤学重点实验室,济宁272067

出　　处：《中国医师杂志》2022年第3期469-472,共4页Journal of Chinese Physician

基　　金：山东省自然科学基金(ZR2010HM040)。

摘　　要：创伤性脊髓损伤(SCI)对患者身体和心理健康具有毁灭性的影响。自噬广泛参与机体的各种生理病理过程,在脊髓损伤中发挥关键作用。雷帕霉素靶蛋白(mTOR)是自噬的主要调节因子。mTOR调控自噬与脊髓损伤病理过程关系密切,可有效促进脊髓损伤的恢复。因此,mTOR是一个很有前景的脊髓损伤治疗靶点。本文就mTOR信号转导通路调控自噬在脊髓损伤中的作用进行综述,以期为后续研究提供参考。Traumatic spinal cord injury(SCI)has devastating effects on patients′physical and mental health.Autophagy is widely involved in various physiological and pathological processes of the body and plays a key role in spinal cord injury.The mammalian target of rapamycin(mTOR)is the main regulator of autophagy.mTOR regulation of autophagy is closely related to the pathological process of spinal cord injury,and can effectively promote the recovery of spinal cord injury.Therefore,mTOR is a promising target for treatment of spinal cord injury.This article reviews the role of mTOR signal transduction pathway in the regulation of autophagy in spinal cord injury,in order to provide reference for follow-up research.

关 键 词：脊髓损伤 自噬 MTOR信号通路 

分 类 号：R651.2[医药卫生—外科学]