女性2型糖尿病合并冠心病患者肠道菌群特征及相关性分析  

Characteristics of intestinal flora in female patients with type 2 diabetes mellitus and coronary heart disease

作　　者：张爱敏 高宇[1] 孙启天 钟敏 高珊 刘晓燕[1] 刘畅[1] 金凤表[1] 何建秋[1] Zhang Aimin;Gao Yu;Sun Qitian;Zhong Min;Gao Shan;Liu Xiaoyan;Liu Chang;Jin Fengbiao;He Jianqiu(Department of Endocrinology,Affiliated Hospital of Chengde Medical University,Chengde 067000,China;Chengde Medical University,Chengde 067000,China)

机构地区：[1]承德医学院附属医院内分泌科,067000 [2]承德医学院,067000

出　　处：《中华内分泌代谢杂志》2022年第2期100-104,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：河北省科技厅"技术创新引导专项-科技工作会商"项目资助;河北省政府资助专科带头人培养项目(2018361008)

摘　　要：目的探讨女性2型糖尿病(T2DM)合并冠心病(CHD)患者肠道菌群特征并进行相关性分析。方法纳入2019年9月至2020年11月女性T2DM患者,依据是否合并冠心病分为两组合并冠心病组(T2DM+CHD组)22例;单纯女性T2DM组(T2DM组)49例。健康女性对照组(NC组)31例。采用实时荧光定量PCR检测技术对3组人群中肠道菌群含量进行检测,分析肠道菌群差异及与HbA1C、空腹血糖等指标之间的关系。结果与NC组比较,T2DM组普雷沃菌属含量降低,T2DM组及T2DM+CHD组普拉梭菌属、罗氏菌属含量降低,拟杆菌属、肠球菌属含量增加,差异均有统计学意义(P<0.05)。与T2DM组比较,T2DM+CHD组拟杆菌属、肠球菌属含量降低,差异具有统计学意义(P<0.05)。Spearman相关性分析显示,普拉梭菌属、直肠真杆菌属与肥胖呈负相关,拟杆菌属、肠球菌属与HbA1C、空腹血糖呈正相关,拟杆菌属与胆固醇、三酰甘油呈正相关(均P<0.05)。Logistic回归分析表明,拟杆菌属和肠球菌属是T2DM合并CHD发病的独立危险因素。结论女性T2DM及T2DM合并CHD患者存在肠道菌群失调,与多种糖脂代谢指标相关,可能与女性发生T2DM及CHD密切相关。拟杆菌属和肠球菌属是女性T2DM合并CHD发病的独立危险因素,调节肠道菌群可以为女性T2DM合并CHD的防治提供思路。Objective To explore the characteristics of intestinal flora in female patients with type 2 diabetes mellitus(T2DM)with comorbid coronary heart disease.Methods Female patients with T2DM from September 2019 to November 2020 were enrolled in this study and divided into 2 groups stratified by coronary heart disease:22 patients with coronary heart disease(T2DM+CHD group)and 49 patients with simple T2DM group(T2DM group).Thirty-one healthy females were selected as the normal control group(NC group).The abundance of intestinal flora,the difference in intestinal flora and its relationship with indicators such as glycosylated hemoglobin and fasting blood glucose was analyzed by the real-time fluorescent quantitative PCR detection technology in the three groups.Results The abundance of Prevotella in the T2DM group was lower,and Roseburia inulinivorans and Faecalibacterium prausnitzii in the T2DM+CHD group were lower,while Bacteroides and Enterococcus spp in the T2DM+CHD group were higher compared with NC group,respectively(P<0.05).The abundance of Bacteroides and Enterococcus spp in the T2DM+CHD group was lower than that in the T2DM group(P<0.05).Spearman correlation analysis showed that the abundance of Faecalibacterium prausnitzii and Eubacterium rectale was negatively correlated with obesity while abundance of Bacteroides and Enterococcus spp was positively correlated with HbA1C and fasting blood glucose.The abundance of Bacteroides was positively correlated with TCH and TG(all P<0.05).Logistic regression analysis showed that Bacteroides and Enterococcus spp were independent influencing factor of the development of female patients with T2DM and CHD.Conclusion Female T2DM and T2DM with CHD had intestinal flora imbalance,which was related to a variety of glucose and lipid metabolism indicators,and might be closely related to the occurrence of T2DM and CHD.Bacteroides and Enterococcus spp were independent influencing factors of the development of female patients with T2DM and CHD.Regulating the intestinal flora can provid

关 键 词：女性 糖尿病 2型 冠心病 肠道菌群 

分 类 号：R587.2[医药卫生—内分泌] R541.4[医药卫生—内科学]