醛固酮合成细胞簇(APCC)在原发性醛固酮增多症发病中的研究进展  

New insights on aldosterone-producing cell clusters in the pathogenesis of primary aldosteronism

作　　者：费娟 杨溢[1] 胡金波[1] 马林强 李俊龙 宋颖[1] 李启富[1] 李晓禹 杨淑敏[1] Fei Juan;Yang Yi;Hu Jinbo;Ma Linqiang;Li Junlong;Song Ying;Li Qifu;Li Xiaoyu;Yang Shumin(Department of Endocrinology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016

出　　处：《中华内分泌代谢杂志》2022年第2期174-178,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81800701);重庆英才青年拔尖人才项目(CQYC2020058096)。

摘　　要：原发性醛固酮增多症(primary aldosteronism,PA)是最常见的继发性高血压之一,但其发病机制尚不完全清楚。传统观念中,醛固酮合成酶(CYP11B2)连续表达于肾上腺皮质球状带。近年来,有学者通过免疫组化染色发现肾上腺皮质存在不连续的CYP11B2阳性细胞团簇,并提出"醛固酮合成细胞簇(aldosterone-producing cell clusters,APCC)"这一概念。后续诸多研究提示,APCC与PA的发病之间可能具有潜在的因果联系。本文就近年来国内外APCC的最新研究进行总结,以期揭示APCC在PA发病中的潜在作用。Primary aldosteronism(PA)is one of the most common secondary hypertension,the pathogenesis is still not fully understood.Aldosterone synthase(CYP11B2)was thought to be continuously expressed in the zona glomerulosa of the adrenal cortex.In recent years,it is found that there were discontinuous CYP11B2 positive cell clusters in adrenal cortex via immunohistochemical staining,and proposed the concept of aldosterone-producing cell clusters(APCC).Thenceforwarding a growing body of studies suggest that there may be a potential causal link between APCC and PA.This article summarizes the latest studies on APCC and provide an update on the potential role of APCC in the pathogenesis of PA.

关 键 词：醛固酮合成细胞簇 原发性醛固酮增多症 醛固酮合成酶 

分 类 号：R586.24[医药卫生—内分泌]